ArticleCephalalgia : an international journal of headache2022
Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families.
Article in Cephalalgia : an international journal of headache, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- The effect of targeted upper cervical musculoskeletal management on the frequency and burden of migraine headache in adults - a single cohort pilot study.The Journal of manual & manipulative therapy · 2026Article
- Beyond air pollution: Green space, water minerals, and genetic predisposition in migraine onset.iScience · 2026Article
- Post-Traumatic Headache in Children and Genetic Risk of Migraine: An Observational Cohort Study.Neurology. Genetics · 2026Article
- Hypothalamic and sex-related hormones in migraine.The journal of headache and pain · 2026Review
- Migraine Genetic Susceptibility Does Not Strongly Influence Migraine Characteristics and Outcomes in a Treated, Real-World, Community Cohort.Journal of clinical medicine · 2025Article
- Development and validation of a diagnostic model for migraine without aura in inpatients.Frontiers in neurology · 2025Article
- Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024Review
- An Integrative Migraine Polygenic Risk Score Is Associated with Age at Onset But Not Chronification.Journal of clinical medicine · 2024Article
- Genetics of migraine: where are we now?The journal of headache and pain · 2023Review
- Migraine may disturb sleep perception during sleep onset: a retrospective data analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
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Authors and funding
16 authors at 9 institutions in 2 countries.
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Abstract
backgroundMigraine is diagnosed using the extensively field-tested International Classification of Headache Disorders (ICHD-3) consensus criteria derived by the International Headache Society. To evaluate the criteria in respect to a measurable biomarker, we studied the relationship between the main ICHD-3 criteria and the polygenic risk score, a measure of common variant burden in migraine.
methodsWe used linear mixed models to study the correlation of ICHD-3 diagnostic criteria, underlying symptoms, and main diagnoses with the polygenic risk score of migraine in a cohort of 8602 individuals from the Finnish Migraine Genome Project.
resultsMain diagnostic categories and all underlying diagnostic criteria formed a consistent continuum along the increasing polygenic burden. Polygenic risk was associated with the heterogeneous clinical picture starting from the non-migraine headache (mean 0.07; 95% CI 0.02-0.12;
conclusionsThe complex migraine phenotype progressively follows the polygenic burden from individuals with no headache to non-migrainous headache and up to patients with attacks manifesting all the features of the ICHD-3 headache and aura. Results provide further biological support for the ICHD-3 diagnostic criteria.
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