Evidence map›Paper›PMID 34648358›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2022

Focused ultrasound stimulation on meibomian glands for the treatment of evaporative dry eye.

Gengxi Lu, Sumanth Gollapudi, Runze Li, Margaret L Pfeiffer, Preeya Mehta, Laiming Jiang, Sarah Hamm-Alvarez, Mark Humayun, Qifa Zhou, Sandy X Zhang-Nunes

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Gengxi LuRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0001-7497-050X
Sumanth GollapudiRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Runze LiRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Margaret L PfeifferRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Preeya MehtaRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Laiming JiangRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Sarah Hamm-AlvarezRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Mark HumayunRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Qifa ZhouRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Sandy X Zhang-NunesRoski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
University of Southern California · US

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
High Resolution Elastograpy of Retina Under Prosthetic Electrical StimulationR01EY026091 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, ZHOU, QIFA · 2016 to 2019
$2.0M
Non-invasive Ultrasound Stimulated Retinal ProsthesisR01EY030126 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHOU, QIFA · 2019 to 2022
$2.0M
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY026091NEI NIH HHS R01 EY028662NEI NIH HHS R01 EY030126
6 · The paper itself

Abstract

Current treatments for meibomian gland dysfunction have several limitations, creating a necessity for other advanced treatment options. The purpose of this study is to determine the effectiveness of focused ultrasound stimulation for the treatment of dry eye disease caused by meibomian gland dysfunction. An

Indexed as

Dry Eye SyndromesMeibomian Gland DysfunctionAnimalsLipidsMeibomian GlandsRabbitsTearsLipidsDry eye diseaseFEM simulationlipid layer thicknessmeibomian gland dysfunctionSchirmer’s testultrasound stimulation

Identifiers

PMID34648358
PMCPMC8943330
OpenAlexW3205539897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.