ArticleScience (New York, N.Y.)2021
Modulation of tactile feedback for the execution of dexterous movement.
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Naturalistic climbing reveals adaptive strategies for interlimb coordination in freely moving mice.iScience · 2026Article
- Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement.Nature communications · 2026Article
- Robust PHP in Adult Hippocampus: Essential Assay Optimizations.bioRxiv : the preprint server for biology · 2026Article
- Medullary and C3-C4 propriospinal pathways underlying mammalian forelimb movement control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Perpendicular neuromorphic channels facilitate lateral inhibition for tactile location.Nature communications · 2026Article
- Expectation Of Tactile Signals In Human Motor Cortex.medRxiv : the preprint server for health sciences · 2025Article
- From thought to action: The organization of spinal projecting neurons.Cell reports · 2025Review
- Descending projection neurons in the primary sensorimotor cortex regulate neuropathic pain and locomotion in mice.Nature communications · 2025Article
- The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states.Cell reports · 2025Article
- A novel biomechanical model of the proximal mouse forelimb predicts muscle activity in optimal control simulations of reaching movements.Journal of neurophysiology · 2025Article
- Emergence of a brainstem somatosensory tonotopic map for substrate vibration.Nature neuroscience · 2025Article
- The Excessive Tonic Inhibition of the Peri-infarct Cortex Depresses Low Gamma Rhythm Power During Poststroke Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Refined movement analysis in the staircase test reveals differential motor deficits in mouse models of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- An output-null signature of inertial load in motor cortex.Nature communications · 2024Article
- Intracortical microstimulation of human somatosensory cortex is sufficient to induce perceptual biases.medRxiv : the preprint server for health sciences · 2024Article
- Large-scale capture of hidden fluorescent labels for training generalizable markerless motion capture models.Nature communications · 2023Article
- Interchangeable Role of Motor Cortex and Reafference for the Stable Execution of an Orofacial Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex.Nature communications · 2023Article
- Noninvasive Brain Stimulation for Neurorehabilitation in Post-Stroke Patients.Brain sciences · 2023Review
- Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies?Annual review of physiology · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Although dexterity relies on the constant transmission of sensory information, unchecked feedback can be disruptive. Yet how somatosensory feedback from the hands is regulated and whether this modulation influences movement remain unclear. We found that mouse tactile afferents recruit neurons in the brainstem cuneate nucleus, whose activity is modulated by distinct classes of local inhibitory neurons. Manipulation of these inhibitory circuits suppresses or enhances the transmission of tactile information, which affects manual behaviors. Top-down cortical pathways innervate cuneate in a complementary pattern, with somatosensory cortical neurons targeting the core tactile region of cuneate and a large rostral cortical population driving feed-forward inhibition of tactile transmission through an inhibitory shell. These findings identify a circuit basis for tactile feedback modulation that enables the effective execution of dexterous movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.