Evidence map›Paper›PMID 34648303›Full record

ArticleScience (New York, N.Y.)2021

Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India.

Mahesh S Dhar, Robin Marwal, Radhakrishnan Vs, Kalaiarasan Ponnusamy, Bani Jolly, Rahul C Bhoyar, Viren Sardana, Salwa Naushin, Mercy Rophina, Thomas A Mellan and 70 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Molecular mechanisms of SARS-CoV-2 entry: implications for biomedical strategies.Microbiology and molecular biology reviews : MMBR · 2025
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147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

80 authors.

Mahesh S Dhar *National Centre for Disease Control, Delhi, India.ORCID 0000-0002-2006-3581
Robin Marwal *National Centre for Disease Control, Delhi, India.ORCID 0000-0002-8314-1743
Radhakrishnan Vs *National Centre for Disease Control, Delhi, India.ORCID 0000-0002-3443-526X
Kalaiarasan Ponnusamy *National Centre for Disease Control, Delhi, India.ORCID 0000-0002-4913-2237
Bani Jolly *CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0001-7969-1606
Rahul C Bhoyar *CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0003-3070-1038
Viren SardanaCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-6735-2946
Salwa NaushinCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-7914-2807
Mercy RophinaCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Thomas A MellanMedical Research Council (MRC) Centre for Global Infectious Disease Analysis, Jameel Institute, School of Public Health, Imperial College London, London, UK.ORCID 0000-0003-4185-9930
Swapnil MishraMedical Research Council (MRC) Centre for Global Infectious Disease Analysis, Jameel Institute, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-8759-5902
Charles WhittakerMedical Research Council (MRC) Centre for Global Infectious Disease Analysis, Jameel Institute, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-5003-2575
Saman FatihiCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-9781-9009
Meena DattaNational Centre for Disease Control, Delhi, India.
Priyanka SinghNational Centre for Disease Control, Delhi, India.ORCID 0000-0003-1801-2002
Uma SharmaNational Centre for Disease Control, Delhi, India.ORCID 0000-0003-2276-6958
Rajat UjjainiyaCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-5090-0432
Nitin BhathejaCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0003-3226-6113
Mohit Kumar DivakarCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-6731-9249
Manoj K SinghNational Centre for Disease Control, Delhi, India.ORCID 0000-0002-0093-4167
Mohamed ImranCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Vigneshwar SenthivelCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Ranjeet MauryaCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-0306-8970
Neha JhaCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0001-9746-2807
Priyanka MehtaCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0001-6298-4322
Vivekanand ACSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0001-8253-7466
Pooja SharmaCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-8859-5971
Arvinden VrCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-1008-1348
Urmila ChaudharyNational Centre for Disease Control, Delhi, India.
Namita SoniNational Centre for Disease Control, Delhi, India.
Lipi ThukralCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-1961-039X
Seth FlaxmanDepartment of Mathematics, Imperial College London, London, UK.ORCID 0000-0002-2477-4217
Samir BhattMedical Research Council (MRC) Centre for Global Infectious Disease Analysis, Jameel Institute, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-0891-4611
Rajesh PandeyCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-4404-8327
Debasis DashCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-5647-3785
Mohammed FaruqCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0001-8278-8396
Hemlata LallNational Centre for Disease Control, Delhi, India.ORCID 0000-0002-7162-6540
Hema GogiaNational Centre for Disease Control, Delhi, India.
Preeti MadanNational Centre for Disease Control, Delhi, India.ORCID 0000-0002-9146-7049
Sanket KulkarniNational Centre for Disease Control, Delhi, India.ORCID 0000-0003-2291-7111
Himanshu ChauhanNational Centre for Disease Control, Delhi, India.
Shantanu SenguptaCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0001-8461-0735
Sandhya KabraNational Centre for Disease Control, Delhi, India.
Indian SARS-CoV-2 Genomics Consortium (INSACOG)‡
Ravindra K GuptaDepartment of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.ORCID 0000-0001-9751-1808
Sujeet K SinghNational Centre for Disease Control, Delhi, India.
Anurag AgrawalCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.ORCID 0000-0002-0340-5252
Partha RakshitNational Centre for Disease Control, Delhi, India.ORCID 0000-0002-8285-1479
Vinay Nandicoori
Karthik Bharadwaj Tallapaka
Divya Tej Sowpati
K Thangaraj
Murali Dharan Bashyam
Ashwin Dalal
Sridhar Sivasubbu
Vinod Scaria
Ajay Parida
Sunil K Raghav
Punit Prasad
Apurva Sarin
Satyajit Mayor
Uma Ramakrishnan
Dasaradhi Palakodeti
Aswin Sai Narain Seshasayee
Manoj Bhat
Yogesh Shouche
Ajay Pillai
Tanzin Dikid
Saumitra Das
Arindam Maitra
Sreedhar Chinnaswamy
Nidhan Kumar Biswas
Anita Sudhir Desai
Chitra Pattabiraman
M V Manjunatha
Reeta S Mani
Gautam Arunachal Udupi
Priya Abraham
Potdar Varsha Atul
Sarah S Cherian

Funding

Medical Research Council MC_PC_19012Medical Research Council MR/R015600/1Medical Research Council MR/V038109/1Wellcome Trust 108082
6 · The paper itself

Abstract

Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.

Indexed as

Genome, ViralAdolescentAdultChildCOVID-19HumansImmune EvasionIndiaMolecular EpidemiologyPhylogenyReinfectionSeroepidemiologic StudiesYoung Adult

Identifiers

PMID34648303
PMCPMC7612010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.