Evidence map›Paper›PMID 34648230›Full record

ArticleChemistryOpen2021

Structure-Activity Relationship Studies of Hydantoin-Cored Ligands for Smoothened Receptor.

Yang Liu, Fang Zhou, Kang Ding, Dongxiang Xue, Zhihao Zhu, Cuixia Li, Fei Li, Yueming Xu, Fei Xu, Zhiping Le and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yang LiuiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Fang ZhouiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Kang DingiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Dongxiang XueiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Zhihao ZhuDepartment of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031, China.
Cuixia LiiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Fei LiiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Yueming XuiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Fei XuiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Zhiping LeDepartment of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031, China.
Suwen ZhaoiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Houchao TaoiHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.ORCID 0000-0001-7598-0275

Funding

GPCR ConsortiumNational Key R&D Program of China 2018YFA0507000Shanghai Municipal GovernmentShanghaiTech University
6 · The paper itself

Abstract

An underside binding site was recently identified in the transmembrane domain of smoothened receptor (SMO). Herein, we report efforts in the exploration of new insights into the interactions between the ligand and SMO. The hydantoin core in the middle of the parent compound was found to be highly conservative in chirality, ring size, and substituents. On each benzene at two ends, a plethora of variations, particularly halogen substitutions, were introduced and investigated. Analysis of the structure-activity relationship revealed miscellaneous halogen effects. The ligands with double halogen substituents exhibit remarkably enhanced potency, providing promising candidates that potentially overcome the common drug resistance and useful heavy-atom labeled chemical tools for co-crystallization studies of SMO.

Indexed as

HydantoinsBinding SitesLigandsSmoothened ReceptorStructure-Activity RelationshipHydantoinsLigandsSmoothened Receptoranti-cancerhalogen bondingmolecular dynamicssmoothened receptorstructural biology

Identifiers

PMID34648230
PMCPMC8515922

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.