Evidence map›Paper›PMID 34648185›Full record

ArticleThe Journal of physiology2021

Sexual dimorphism in intestinal absorption and lymphatic transport of dietary lipids.

Min Liu, Ling Shen, Qing Yang, Andromeda M Nauli, Madison Bingamon, David Q-H Wang, Yvonne M Ulrich-Lai, Patrick Tso

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Transport functions of intestinal lymphatic vessels.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Mechanisms and functions of intestinal vascular specialization.The Journal of experimental medicine · 2024
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Min LiuDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0003-2505-0218
Ling ShenDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Qing YangDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Andromeda M NauliDepartment of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, Fullerton, CA, USA.
Madison BingamonNorthern Kentucky University, Louie B Nunn Dr, Highland Heights, KY, USA.
David Q-H WangDepartment of Medicine and Genetics, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Yvonne M Ulrich-LaiDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Patrick TsoDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
University of Cincinnati Medical Center · USAlbert Einstein College of Medicine · USMarshall B. Ketchum University · USNorthern Kentucky University · US

Funding

LIPID, LIPOPROTEIN, AND GLUCOSE METABOLISM COREU24DK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2001 to 2015
$12.9M
Lipid profile, lipoprotein and apolipoprotein composition, and intestinal fat absorption efficiency in germ-free and conventional miceU2CDK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN · 2016 to 2021
$4.9M
Role of the GI lymphatic system in hormonal signaling and nutrient metabolismR01DK119135 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, TSO, PATRICK · 2018 to 2022
$3.0M
The therapeutic potential of smarter exosomes derived from engineered MSCs on Alzheimer's diseaseR01HL140962 · NHLBI · UNIVERSITY OF CINCINNATI · PI LIU, MIN, XU, MEIFENG · 2018 to 2021
$2.4M
GPR30 and hepatic cholesterol metabolismR01DK126369 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI PESSIN, JEFFREY E. · 2020 to 2023
$1.9M
Brain apoA-IV Mediates Estrogenic Reduction of Dietary Obesity in Female RatsR01DK092779 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, WOODS, STEPHEN C · 2011 to 2015
$1.8M
Ginsenocide Rb1: A Novel Anti-Obesity and Anti-Hyperglycemic CompoundR01DK095440 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, WOODS, STEPHEN C · 2012 to 2016
$1.6M
GPR30 and Hepatic Cholesterol HomeostasisR01DK106249 · NIDDK · SAINT LOUIS UNIVERSITY · PI WANG, DAVID Q · 2015 to 2017
$1.0M
NHLBI NIH HHS R01 HL140962NIDDK NIH HHS R01 DK092779NIDDK NIH HHS R01 DK095440NIDDK NIH HHS R01 DK106249NIDDK NIH HHS R01 DK119135NIDDK NIH HHS R01 DK126369NIDDK NIH HHS U24 DK059630NIDDK NIH HHS U2C DK059630
6 · The paper itself

Abstract

Although the basic process of intestinal lipid absorption and transport is understood, many critical aspects remain unclear. One question in particular is whether intestinal lipid absorption and transport differ between the sexes. Using a well-established lymph fistula model, we found that intact female mice exhibited lower lymphatic output of triacylglycerol (TAG) than male mice. Further analysis revealed that the female mice segregated into two groups: the high group having similar lymphatic TAG transport to the males, and the low group having significantly less lymphatic output, implying the impact of cyclical variation of ovarian hormonal levels. These led us to examine whether oestradiol (E2) and progesterone (P) affect intestinal absorption and lymphatic transport of dietary lipids. In ovariectomized (OVX) rats, E2 treatment significantly reduced [

Indexed as

Sex CharacteristicsVascular Endothelial Growth Factor AAnimalsDietary FatsFemaleIntestinal AbsorptionIntestinal MucosaLymphLymphatic SystemMaleMiceRatsTriglyceridesDietary FatsTriglyceridesVascular Endothelial Growth Factor Aapolipoproteinscholesterollymphatic lipid transportoestrogenprogesteronetriacylglycerol

Identifiers

PMID34648185
PMCPMC8595769
OpenAlexW3205042847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.