Evidence map›Paper›PMID 34648147›Full record

ArticleDermatology and therapy2021

Validation of the Self-Reported Psoriasis Treatment Convenience Scale (PTCS).

Steven R Feldman, Morten Præstegaard, Arne H Andreasen, Johan Selmer, Tove Holm-Larsen

Registry-linked trialAbstract read
In one paragraph

Article in Dermatology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03308799 (A Randomised, Multicentre, Investigator-Blind, Parallel-Group Trial to Evaluate the Efficacy and Safety of MC2-01 Cream Compared to Vehicle and Active Comparator in Subjects With Mild-to-Moderate Psoriasis Vulgaris), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03308799 phase3completednot on this map

A Randomised, Multicentre, Investigator-Blind, Parallel-Group Trial to Evaluate the Efficacy and Safety of MC2-01 Cream Compared to Vehicle and Active Comparator in Subjects With Mild-to-Moderate Psoriasis Vulgaris

TypeinterventionalSponsorMC2 TherapeuticsRan2017 to 2018Enrolled794ConditionsPsoriasis VulgarisArmsMC2-01 cream, Cal/BDP combination, Cream vehicle
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Steven R FeldmanCenter for Dermatology Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Morten PræstegaardMC2 Biotek, Hørsholm, Denmark.
Arne H AndreasenStatgroup ApS, Copenhagen, Denmark.
Johan SelmerMC2 Biotek, Hørsholm, Denmark.
Tove Holm-LarsenPharma Evidence, Copenhagen, Denmark. thl@pharmaevidence.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAdherence to topical treatments for psoriasis is reported to be poor. One key contributing factor is the inconvenience associated with formulations that may be greasy, time consuming to apply, and slow to absorb. There is a paucity of patient-reported outcome measures that evaluate psoriasis patients' perceptions of treatment convenience. The Psoriasis Treatment Convenience Scale (PTCS) was therefore developed and validated.

methodsFollowing a literature review of issues relating to convenience of topical treatments, important items were identified and a draft version of the PTCS was developed and underwent content validity testing (n = 20). The revised scale was included in a clinical trial of topical therapy (n = 794; NCT03308799), and psychometric testing was performed.

resultsThe final questionnaire included five core items and one overall satisfaction question. In psychometric testing, the scale demonstrated stability across trial population, and good validity, reliability, and sensitivity.

conclusionThe PTCS is a new, reliable, sensitive, validated tool for the assessment of patient-reported treatment convenience. Use of the PTCS will facilitate evaluation of convenience as part of the clinical development of topical therapies, and thus may help to improve patient adherence and, therefore, treatment outcomes.

Indexed as

ConveniencePatient-reported outcome measuresPsoriasisTreatment adherence and compliance

Identifiers

PMID34648147
PMCPMC8611138

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.