Evidence map›Paper›PMID 34648084›Full record

Observational studyActa diabetologica2022

A 646C > G (rs41423247) polymorphism of the glucocorticoid receptor as a risk factor for hyperglycaemia diagnosed in pregnancy-data from an observational study.

Agnieszka Zawiejska, Anna Bogacz, Rafał Iciek, Agnieszka Lewicka-Rabska, Maciej Brązert, Przemysław Mikołajczak, Jacek Brązert

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta diabetologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Familial Linkage and Association of theInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Agnieszka ZawiejskaChair of Medical Education, Department of Medical Simulation, Poznan University of Medical Sciences, Poznan, Poland. azawiejska@ump.edu.pl.ORCID http://orcid.org/0000-0002-3616-6550
Anna BogaczInstitute of Natural Fibers and Medicinal Plants, National Research Institute, Poznan, Poland.ORCID http://orcid.org/0000-0001-5455-8315
Rafał IciekDepartment of Obstetrics and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland.ORCID http://orcid.org/0000-0001-5025-9350
Agnieszka Lewicka-RabskaDepartment of Hypertension, Angiology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.ORCID http://orcid.org/0000-0003-2218-6646
Maciej BrązertDepartment of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.ORCID http://orcid.org/0000-0002-2423-8238
Przemysław MikołajczakChair of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland.ORCID http://orcid.org/0000-0002-1252-6523
Jacek BrązertDepartment of Obstetrics and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Poznan University of Medical Sciences · PLInstitute of Natural Fibres and Medicinal Plants · PL

Funding

This research program was funded from a NATIONAL SCIENCE CENTRE POLAND, grant No NN407536538 No NN407536538
6 · The paper itself

Abstract

aimHyperglycaemia diagnosed in pregnancy (HiP) is a serious and frequent complication of pregnancy, increasing the risk for adverse maternal and neonatal outcomes. Investigate whether allelic variations of the glucocorticoid receptor are related to an increased risk of HiP.

methodThe following polymorphisms of the glucocorticoid receptor (GR) were investigated in the cohort study of N = 197 pregnant women with HiP and N = 133 normoglycemic pregnant controls: 646C > G (rs41423247), N363S (rs6195), ER23/22EK (rs6190, rs6189).

resultsA GG variant of the rs41423247 polymorphism was associated with a significantly higher risk for HiP: OR 1.94 (1.18; 3.18), p = 0.009. The relationship remained significant after controlling for maternal age and prepregnancy BMI: OR 3.09 (1.25; 7.64), p = 0.014.

conclusionsThe allelic GG variant of the 646C > G (rs41423247) polymorphism is associated with an increased risk for hyperglycaemia in pregnancy.

Indexed as

HyperglycemiaReceptors, GlucocorticoidCohort StudiesFemaleHumansInfant, NewbornPolymorphism, Single NucleotidePregnancyRisk FactorsReceptors, GlucocorticoidDiabetes diagnosed in pregnancyGestational diabetes mellitusGlucocorticoid receptorHyperglycaemia detected in pregnancyrs41423247 polymorphism

Identifiers

PMID34648084
PMCPMC8841327
OpenAlexW3205540827

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.