Evidence map›Paper›PMID 34648073›Full record

ArticleBasic research in cardiology2021

Cardiomyocyte Na

Bence Hegyi, Risto-Pekka Pölönen, Kim T Hellgren, Christopher Y Ko, Kenneth S Ginsburg, Julie Bossuyt, Mark Mercola, Donald M Bers

Open access · hybridAbstract read
In one paragraph

Article in Basic research in cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 83 citations in OpenAlex.

  1. Trial
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  12. mBio · 2026
    Article
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  15. Review
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  18. Article
  19. Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bence HegyiDepartment of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.
Risto-Pekka PölönenDepartment of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.
Kim T HellgrenDepartment of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.
Christopher Y KoDepartment of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.
Kenneth S GinsburgDepartment of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.
Julie BossuytDepartment of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.
Mark MercolaCardiovascular Institute and Department of Medicine, Stanford University, Stanford, CA, 94305, USA.
Donald M BersDepartment of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA. dmbers@ucdavis.edu.ORCID http://orcid.org/0000-0002-2237-9483
University of California, Davis · USCardiovascular Institute of the South · US

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
MicroRNA Control of Dilated CardiomyopathyR01HL130840 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA, Shankar Subramaniam · 2016 to 2026
$4.6M
High-Throughput Screens to Discover Novel Inhibitors of Leaky RyR2 for Heart Failure TherapyR01HL138539 · NHLBI · UNIVERSITY OF MINNESOTA · PI BERS, DONALD M, CORNEA, RAZVAN LIVIU · 2018 to 2021
$3.1M
NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL130840NHLBI NIH HHS R01 HL138539NHLBI NIH HHS R01 HL142282NIH HHS P01-141084NIH HHS R01-142282
6 · The paper itself

Abstract

Cardiomyocyte Na

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2Induced Pluripotent Stem CellsAction PotentialsAnimalsCalciumFemaleHumansMyocytes, CardiacPregnancyRabbitsReactive Oxygen SpeciesRyanodine Receptor Calcium Release ChannelCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Reactive Oxygen SpeciesRyanodine Receptor Calcium Release ChannelCalciumCaMKIIElectrophysiologyHeart failureROSRyR

Identifiers

PMID34648073
PMCPMC8516771
OpenAlexW3207515186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.