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ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022

Pachychoroid disease spectrum: review article.

Thiago José Muniz Machado Mazzeo, Henrique Monteiro Leber, Allan Gomes da Silva, Raimunda Cristina Mendonça Freire, Gabriel Castilho Sandoval Barbosa, Guilherme Garcia Criado, Gabriel Almeida Veiga Jacob, Cleide Guimarães Machado, André Marcelo Vieira Gomes

Abstract readReview
PubMed Publisher
In one paragraph

Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Three-dimensional choroidal characteristics in different subtypes of central serous chorioretinopathy using swept-source optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Trial
  2. Observational
  3. Article
  4. The spectrum of pachychoroid neovasculopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  5. Article
  6. Imaging in Pachychoroid DiseaseTurkish journal of ophthalmology · 2025
    Review
  7. Review
  8. Pachychoroid pigment epitheliopathy in keratoconic eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Observational
  9. Article
  10. Article
  11. Observational
  12. Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thiago José Muniz Machado MazzeoRetina and Vitreous Department, Suel Abujamra Institute, São Paulo, Brazil. mazzeothiago@yahoo.com.
Henrique Monteiro LeberRetina and Vitreous Department, Suel Abujamra Institute, São Paulo, Brazil.
Allan Gomes da SilvaRetina and Vitreous Department, Suel Abujamra Institute, São Paulo, Brazil.
Raimunda Cristina Mendonça FreireRetina and Vitreous Department, Suel Abujamra Institute, São Paulo, Brazil.
Gabriel Castilho Sandoval BarbosaRetina and Vitreous Department, Suel Abujamra Institute, São Paulo, Brazil.
Guilherme Garcia CriadoRetina and Vitreous Department, University of São Paulo (USP), São Paulo, Brazil.
Gabriel Almeida Veiga JacobRetina and Vitreous Department, Suel Abujamra Institute, São Paulo, Brazil.
Cleide Guimarães MachadoRetina and Vitreous Department, Suel Abujamra Institute, São Paulo, Brazil.
André Marcelo Vieira GomesRetina and Vitreous Department, Suel Abujamra Institute, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this article is to do a comprehensive literature review about the current understandings of the pachychoroid disease spectrum, describing its multimodal imaging analysis, pathophysiology, differential diagnosis, and current types of management.

methodsThis comprehensive literature review was performed based on a search on the PubMed database, of relevant pachychoroid published papers according to our current knowledge. DISCUSSION: The pachychoroid disease spectrum, according to some authors, includes the following: pachychoroid pigment epitheliopathy (PPE), central serous chorioretinopathy (CSC), pachychoroid neovasculopathy (PNV), polypoidal choroidal vasculopathy (PCV)/aneurysmal type 1 neovascularization (AT1), and more recently focal choroidal excavation (FCE) and peripapillary pachychoroid syndrome (PPS). Each one of these entities will be described and discussed in this article.

conclusionSignificant advances in multimodal imaging have enabled a better understanding of the typical choroidal changes in pachychoroid disease spectrum. The clinical knowledge and managing options about this disease significantly increased in the last years. However, it is still unclear why some eyes with typical pachychoroid disease phenotype show no evidence of RPE damage and subretinal fluid (uncomplicated pachychoroid) while others present progressive tissue damage, neovascularization, and atrophy.

Indexed as

Central Serous ChorioretinopathyChoroid DiseasesChoroidFluorescein AngiographyHumansRetrospective StudiesTomography, Optical CoherenceAnti-VEGF therapyCentral serous chorioretinopathyMultimodal retinal imagingPachychoroidPhotodynamic therapyPolypoidal choroidal vasculopathy

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.