Evidence map›Paper›PMID 34648031›Full record

ArticleNucleic acids research2022

NCATS Inxight Drugs: a comprehensive and curated portal for translational research.

Vishal B Siramshetty, Ivan Grishagin, Ðắc-Trung Nguyễn, Tyler Peryea, Yulia Skovpen, Oleg Stroganov, Daniel Katzel, Timothy Sheils, Ajit Jadhav, Ewy A Mathé and 1 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. US postmarketed drug removals: Analysis of discontinued and withdrawn drugs.The Journal of pharmacology and experimental therapeutics · 2026
    Review
  3. Article
  4. Nanosystems for delivery of indolicidin peptide.Frontiers in medical technology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Drug-disease networks and drug repurposing.PLoS computational biology · 2025
    Article
  9. DrIVeNN: Drug Interaction Vectors Neural Network.Journal of computational biology : a journal of computational molecular cell biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. The Growing Class of Novel RNAi Therapeutics.Molecular pharmacology · 2024
    Review
  17. Machine Learned Classification of Ligand Intrinsic Activities at HumanbioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Small Molecule Drugs Targeting Viral Polymerases.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vishal B SiramshettyNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-5980-8288
Ivan GrishaginNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0003-2985-4336
Ðắc-Trung NguyễnNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0003-2591-9948
Tyler PeryeaNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-5388-9750
Yulia SkovpenRancho BioSciences, San Diego, CA, USA.ORCID 0000-0003-3570-9776
Oleg StroganovRancho BioSciences, San Diego, CA, USA.ORCID 0000-0001-6190-823X
Daniel KatzelNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-3191-0694
Timothy SheilsNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-9987-3738
Ajit JadhavNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-7955-1451
Ewy A MathéNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0003-4491-8107
Noel T SouthallNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0003-4500-880X

Funding

Inxight Informatics System - Repository of Therapeutic HypothesesZIATR000058 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI MATHE, EWY · 2015 to 2022
$17.9M
6 · The paper itself

Abstract

The United States has a complex regulatory scheme for marketing drugs. Understanding drug regulatory status is a daunting task that requires integrating data from many sources from the United States Food and Drug Administration (FDA), US government publications, and other processes related to drug development. At NCATS, we created Inxight Drugs (https://drugs.ncats.io), a web resource that attempts to address this challenge in a systematic manner. NCATS Inxight Drugs incorporates and unifies a wealth of data, including those supplied by the FDA and from independent public sources. The database offers a substantial amount of manually curated literature data unavailable from other sources. Currently, the database contains 125 036 product ingredients, including 2566 US approved drugs, 6242 marketed drugs, and 9684 investigational drugs. All substances are rigorously defined according to the ISO 11238 standard to comply with existing regulatory standards for unique drug substance identification. A special emphasis was placed on capturing manually curated and referenced data on treatment modalities and semantic relationships between substances. A supplementary resource 'Novel FDA Drug Approvals' features regulatory details of newly approved FDA drugs. The database is regularly updated using NCATS Stitcher data integration tool that automates data aggregation and supports full data access through a RESTful API.

Indexed as

Databases, FactualDatabases, PharmaceuticalUnited States Food and Drug AdministrationHumansNational Center for Advancing Translational Sciences (U.S.)Pharmaceutical PreparationsTranslational Research, BiomedicalUnited StatesPharmaceutical Preparations

Identifiers

PMID34648031
PMCPMC8728186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.