Evidence map›Paper›PMID 34647905›Full record

Observational studyAging2021

Differential moderation effects of ApoE and 5-HTTLPR genotypes on social vulnerability in predicting mortality among community-dwelling middle-aged and older adults: a nationwide population-based study.

Hsin-Yu Liu, Li-Ning Peng, Wei-Ju Lee, Ming-Yueh Chou, Chih-Kuang Liang, Fei-Yuan Hsiao, Ming-Hsien Lin, Liang-Kung Chen

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Hsin-Yu LiuAging and Health Research Center, National Yang Ming Chiao Tung University Yangming Campus, Taipei City, Taiwan.
Li-Ning PengAging and Health Research Center, National Yang Ming Chiao Tung University Yangming Campus, Taipei City, Taiwan.
Wei-Ju LeeAging and Health Research Center, National Yang Ming Chiao Tung University Yangming Campus, Taipei City, Taiwan.
Ming-Yueh ChouAging and Health Research Center, National Yang Ming Chiao Tung University Yangming Campus, Taipei City, Taiwan.
Chih-Kuang LiangAging and Health Research Center, National Yang Ming Chiao Tung University Yangming Campus, Taipei City, Taiwan.
Fei-Yuan HsiaoGraduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei City, Taiwan.
Ming-Hsien LinAging and Health Research Center, National Yang Ming Chiao Tung University Yangming Campus, Taipei City, Taiwan.
Liang-Kung ChenAging and Health Research Center, National Yang Ming Chiao Tung University Yangming Campus, Taipei City, Taiwan.
National Yang Ming Chiao Tung University · TWKaohsiung Veterans General Hospital · TWTaipei Veterans General Hospital · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a dynamic complex process involving social vulnerability over time. The social vulnerability index (SVI) was developed that predicted adverse health outcomes. This study examined effects between SVI status and two genotypes, apolipoprotein E (ApoE) and Serotonin transporter genotyping (5-HTTLPR), on all-cause mortality. Data from the Social Environment and Biomarkers of Aging Study (SEBAS) were obtained, and SVI was constructed using 32 self-reported items of social determinants. Data from 985 participants (age: 65.73 ± 9.47 years, 54.62% males) were obtained for analysis, and the median SVI was 0.35 (IQR 0.29-0.42) with a near normal distribution. Participants with a higher SVI were more likely to be women and have poor cognitive function, more depressive symptoms and poor physical function. Adjusted for age and sex, each incremental deficit in SVI was associated with a 12% increase in mortality risk (HR: 1.12, 95% CI: 1.04-1.20,

Indexed as

MortalityAgedApolipoproteins EFemaleGene-Environment InteractionGenotypeHumansIndependent LivingLongitudinal StudiesMaleMiddle AgedSerotonin Plasma Membrane Transport ProteinsSocial Determinants of HealthSocial VulnerabilityApoE protein, humanApolipoproteins ESerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanapolipoprotein E gene (ApoE)gene-environment interactionserotonin transporter polymorphism (5-HTTLPR)social vulnerabilitysurvival

Identifiers

PMID34647905
PMCPMC8544323
OpenAlexW3207880281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.