ArticleeLife2021
The generation of cortical novelty responses through inhibitory plasticity.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation.Journal of neuroengineering and rehabilitation · 2025Trial
- Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Visual learning at fast and slow timescales is driven by distinct plasticity rules in primate inferotemporal cortex.Nature communications · 2026Article
- Disinhibitory signaling enables flexible coding of top-down information in cortical networks.PLoS biology · 2026Article
- Signed motif analysis of the Caenorhabditis elegans neuronal network reveals positive feedforward and negative feedback loops.BMC biology · 2026Article
- Constructing biologically constrained RNNs via Dale's backpropagation and topologically informed pruning.Science advances · 2025Article
- Predictive Coding Light.Nature communications · 2025Article
- Article
- Cooperative actions of interneuron families support the hippocampal spatial code.Science (New York, N.Y.) · 2025Article
- Balancing complexity, performance and plausibility to meta learn plasticity rules in recurrent spiking networks.PLoS computational biology · 2025Article
- Hallmarks of Brain Plasticity.Biomedicines · 2025Review
- CONSTRUCTING BIOLOGICALLY CONSTRAINED RNNS VIA DALE'S BACKPROP AND TOPOLOGICALLY-INFORMED PRUNING.bioRxiv : the preprint server for biology · 2025Article
- Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex.eLife · 2025Article
- Structural influences on synaptic plasticity: The role of presynaptic connectivity in the emergence of E/I co-tuning.PLoS computational biology · 2024Article
- Inhibitory plasticity supports replay generalization in the hippocampus.Nature neuroscience · 2024Article
- Coordinated changes in a cortical circuit sculpt effects of novelty on neural dynamics.Cell reports · 2024Article
- Simple synaptic modulations implement diverse novelty computations.Cell reports · 2024Article
- Simple synaptic modulations implement diverse novelty computations.bioRxiv : the preprint server for biology · 2024Article
- Concurrent Encoding of Sequence Predictability and Event-Evoked Prediction Error in Unfolding Auditory Patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Behavior-relevant top-down cross-modal predictions in mouse neocortex.Nature neuroscience · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals depend on fast and reliable detection of novel stimuli in their environment. Neurons in multiple sensory areas respond more strongly to novel in comparison to familiar stimuli. Yet, it remains unclear which circuit, cellular, and synaptic mechanisms underlie those responses. Here, we show that spike-timing-dependent plasticity of inhibitory-to-excitatory synapses generates novelty responses in a recurrent spiking network model. Inhibitory plasticity increases the inhibition onto excitatory neurons tuned to familiar stimuli, while inhibition for novel stimuli remains low, leading to a network novelty response. The generation of novelty responses does not depend on the periodicity but rather on the distribution of presented stimuli. By including tuning of inhibitory neurons, the network further captures stimulus-specific adaptation. Finally, we suggest that disinhibition can control the amplification of novelty responses. Therefore, inhibitory plasticity provides a flexible, biologically plausible mechanism to detect the novelty of bottom-up stimuli, enabling us to make experimentally testable predictions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.