Evidence map›Paper›PMID 34647829›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

A model of anemic tissue perfusion after blood transfusion shows critical role of endothelial response to shear stress stimuli.

Weiyu Li, Amy G Tsai, Marcos Intaglietta, Daniel M Tartakovsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Physiologic effects of different hemodynamic patterns of LVAD.Frontiers in cardiovascular medicine · 2025
    Review
  2. Hypertonic treatment of acute respiratory distress syndrome.Frontiers in bioengineering and biotechnology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Weiyu LiDepartment of Energy Resources Engineering, Stanford University, Stanford, California.
Amy G TsaiDepartment of Bioengineering, University of California, San Diego, California.
Marcos IntagliettaDepartment of Bioengineering, University of California, San Diego, California.
Daniel M TartakovskyDepartment of Energy Resources Engineering, Stanford University, Stanford, California.ORCID 0000-0001-9019-8935
Stanford University · USUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although some of the cardiovascular responses to changes in hematocrit (Hct) are not fully quantified experimentally, available information is sufficient to build a mathematical model of the consequences of treating anemia by introducing RBCs into the circulation via blood transfusion. We present such a model, which describes how the treatment of normovolemic anemia with blood transfusion impacts oxygen (O

Indexed as

AnemiaBlood TransfusionEndotheliumHumansPerfusionStress, Mechanicalblood transfusionendothelial responsemathematical model

Identifiers

PMID34647829
PMCPMC8714982
OpenAlexW3206447856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.