Evidence map›Paper›PMID 34647492›Full record

ReviewAnnals of medicine2021

Gastrointestinal microbiome and gluten in celiac disease.

Xingxing Wu, Lin Qian, Kexin Liu, Jing Wu, Zhaowei Shan

Open access · goldAbstract readReview
In one paragraph

Review in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Celiac Disease: Beyond Diet and Food Awareness.Foods (Basel, Switzerland) · 2025
    Review
  12. Variations in gut microbiota in celiac disease patients: a systematic review.Gastroenterology and hepatology from bed to bench · 2025
    Review
  13. Article
  14. Article
  15. The Role of Gluten in the Development of Autoimmune Thyroid Diseases: A Narrative Review.International journal of endocrinology and metabolism · 2024
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xingxing WuAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Lin QianAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Kexin LiuAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Jing WuAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Zhaowei ShanAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Nanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coeliac disease (CD), also known as gluten sensitive enteropathy, is an autoimmune intestinal disease induced by gluten in genetically susceptible individuals. Gluten is a common ingredient in daily diet and is one of the main environmental factors to induce coeliac disease. Adhering to gluten free diet (GFD) is an effective method for treating CD. Microbiota plays an extremely important role in maintaining human health, and diet is the main factor to regulate the composition and function of gut microbiota. Recent studies have shown that gluten metabolism is closely related to gastrointestinal tract (GIT) microbiota. With the increasing prevalence of coeliac disease, there is a need for alternative treatments to GFD. In this review, biological medication of gluten, relationship between gluten and gut microflora, effect of GFD on GIT microflora, and effect of probiotics on CD were reviewed. By analysing the research progress on relationship between gluten and gastrointestinal microbiome in coeliac disease, this review tried to explore the prospective and potential mechanism of microecological agents in treating coeliac disease.

Indexed as

Diet, Gluten-FreeGastrointestinal MicrobiomeCeliac DiseaseGlutensHumansProbioticsProspective StudiesGlutenscoeliac diseasegastrointestinal microbiomeGlutengluten free dietprobiotics

Identifiers

PMID34647492
PMCPMC8519548
OpenAlexW3205785723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.