SynthesisObesity surgery2021
Impact of Intraoperative Ketamine on Postoperative Analgesic Requirement Following Bariatric Surgery: a Meta-analysis of Randomized Controlled Trials.
Synthesis in Obesity surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 9 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Esmolol as an Adjunct in Multimodal Anesthesia: A Systematic Review and Meta-Analysis of Its Opioid-Sparing and Analgesic Effects.Anesthesia and analgesia · 2026Pooled it
- Evaluating the Role of Ketamine in Multimodal Analgesia for Postoperative Pain Management in Bariatric Surgery: A Meta-Analysis of Randomized Controlled Trials.Obesity surgery · 2026Pooled it
- Efficacy and safety of ketamine and esketamine for preventing opioid-induced cough: a systematic review and meta-analysis of randomized controlled trials.Systematic reviews · 2025Pooled it
- Efficacy of Erector Spinae Plane Block on Analgesic Outcomes in Patients Undergoing Metabolic Surgery: A Meta-Analysis of Randomized Controlled Trials.Obesity surgery · 2025Pooled it
- Effects of Intravenous Lidocaine on Quality of Recovery After Laparoscopic Bariatric Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Obesity surgery · 2024Pooled it
- Efficacy and safety of videolaryngoscopes for transesophageal echocardiography probe insertion: A trial sequential meta-analysis.PloS one · 2024Pooled it
- Impact of Opioid-Free Anesthesia on Analgesia and Recovery Following Bariatric Surgery: a Meta-Analysis of Randomized Controlled Studies.Obesity surgery · 2022Pooled it
- Analgesic Efficacy of Gabapentin and Pregabalin in Patients Undergoing Laparoscopic Bariatric Surgeries: a Systematic Review and Meta-analysis.Obesity surgery · 2022Pooled it
- Analgesic efficacy and risk of low-to-medium dose intrathecal morphine in patients undergoing cardiac surgery: An updated meta-analysis.Frontiers in medicine · 2022Pooled it
- Opioid-free anesthesia in bariatric surgery: a prospective randomized controlled trial.European journal of medical research · 2025Trial
- Oxycodone versus Sufentanil for Postoperative Recovery in Obese Patients Undergoing Laparoscopic Bariatric Surgery: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Effect of Intravenous Esketamine on Rebound Pain Following Single-Shot Brachial Plexus Block in Patients Undergoing Shoulder Arthroscopic Surgery: A Prospective, Randomized, Placebo-Controlled Study.Journal of pain research · 2025Article
- Perioperative Ketamine Exposure and Postoperative Atrial Fibrillation/Flutter Risk After Video-Assisted Thoracoscopic Surgery: A Multi-Institutional Study.Drug design, development and therapy · 2025Article
- Neuroinflammatory Approach to Surgical Trauma: Biomarkers and Mechanisms of Immune and Neuroendocrine Responses.Journal of personalized medicine · 2024Review
- Comment to: Efficacy and safety of mesh non‑fixation in patients undergoing laparo‑endoscopic repair of groin hernia.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Laparoscopic Roux-en-Y Gastric Bypass to Improve Remission Rates of Type 2 Diabetes Mellitus: a Trial Sequential Analysis.Obesity surgery · 2024Article
- Comment on "The efficacy and safety of SGLT2 inhibitors in patients with non-diabetic chronic kidney disease".International urology and nephrology · 2024Article
- Comment on: "A meta‑analysis between robotic hepatectomy and conventional open hepatectomy".Journal of robotic surgery · 2024Article
- Comment on: "A systematic review and meta-analysis of short-term outcomes comparing the efficacy of robotic versus laparoscopic colorectal surgery in obese patients".Journal of robotic surgery · 2024Article
- Non-Opioid Analgesics and Adjuvants after Surgery in Adults with Obesity: Systematic Review with Network Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis aimed at exploring the impact of intravenous ketamine on pain relief and analgesic consumption in patients undergoing bariatric surgery (BS). Literature searches identified nine eligible trials with 458 participants. Forest plot revealed a significantly lower pain score [mean difference (MD) = - 1.06, p = 0.005; 390 patients) and morphine consumption (MD = - 3.85 mg, p = 0.01; 212 patients) immediately after BS in patients with intravenous ketamine than in those without. In contrast, pooled analysis showed comparable pain score (p = 0.28), morphine consumption (p = 0.45) within 24 h, and risk of postoperative nausea/vomiting (p = 0.67) between the two groups. In conclusion, the meta-analysis demonstrated improvements in pain outcomes immediately after surgery through perioperative intravenous ketamine administration despite the absence of analgesic benefit in the late postoperative period and a positive impact on postoperative nausea/vomiting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.