Evidence map›Paper›PMID 34647149›Full record

ArticleWorld journal of surgery2022

Parathyroid Hormone Disturbances in Postmenopausal Women with Distal Forearm Fracture.

Axel Wihlborg, Karin Bergström, Paul Gerdhem, Ingrid Bergström

2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in World journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05346419 nacompletednot on this map

Risedronate With High-dose Vitamin D Resolves Hyperparathyroidism and Hypovitaminosis D But Not Osteoporosis in Mexican Postmenopausal Patients

TypeinterventionalSponsorHospital Regional 1o de OctubreRan2021 to 2022Enrolled33ConditionsPostmenopausal Osteoporosis, Hypovitaminosis D, HyperparathyroidismArmsRisedronate, Vitamin D
NCT05347082 nacompletednot on this map

Resolution of Hyperparathyroidism With High-dose Vitamin D Improves Osteoporosis in Multi-treated Postmenopausal Women

TypeinterventionalSponsorHospital Regional 1o de OctubreRan2021 to 2022Enrolled47ConditionsPostmenopausal Osteoporosis, Postmenopause, Hyperparathyroidism, Secondary, Hypovitaminosis DArmsCholecalciferol
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Axel WihlborgDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Solna, Sweden. axel.wihlborg@sll.se.ORCID 0000-0002-5355-9655
Karin BergströmKarolinska Institutet. Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.
Paul GerdhemDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Solna, Sweden.
Ingrid BergströmDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Solna, Sweden.
Karolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary hyperparathyroidism (PHPT) is a common endocrine disorder with a wide range of adverse effects, such as osteoporosis. Many women are not diagnosed due to asymptomatic disease or vague symptoms but are still at risk of severe adverse effects. Early identification of patients with PHPT is therefore of importance. The aim of this study was to determine PHPT prevalence among postmenopausal women with a distal forearm fracture.

methodsRecruitment was conducted in conjunction with the occurrence of a distal forearm fracture at Karolinska University Hospital. In total, 161 postmenopausal women were included in a cross-sectional study with repeated evaluations. Analyzes of serum calcium, ionized calcium, phosphate, parathyroid hormone (PTH), and vitamin D were performed. Diagnosis of PHPT was based on clinical evaluations and biochemical definitions of serum calcium and PTH in coherence with previous population prevalence reports.

resultsMean age was 64.7 (9.5) years, serum calcium 2.33 (0.10) mmol/L, ionized calcium 1.25 (0.05) mmol/L and PTH 54 (26) ng/L. PTH was elevated in 32 (20%) women. In total, 11 (6.8%) women were diagnosed with PHPT; 6 with classical PHPT and 5 with mild PHPT. The prevalence of PHPT was significantly increased compared to the population prevalence of 3.4% (p = 0.022).

conclusionScreening postmenopausal women in conjunction with low-energy distal forearm fracture revealed a large number of women with parathyroid disturbance. Evaluation of parathyroid hormone and calcium status in this group of patients seems beneficial.

Indexed as

Hyperparathyroidism, PrimaryPostmenopauseCalciumCross-Sectional StudiesFemaleForearmHumansMiddle AgedParathyroid HormoneCalciumParathyroid Hormone

Identifiers

PMID34647149
PMCPMC8677684
OpenAlexW3205237495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.