Evidence map›Paper›PMID 34647039›Full record

ArticleSTAR protocols2021

Quantitative neuronal morphometry by supervised and unsupervised learning.

Kayvan Bijari, Gema Valera, Hernán López-Schier, Giorgio A Ascoli

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Cell morphologies in the nervous system: Glia steal the limelight.The Journal of comparative neurology · 2023
    Article
  5. Circuit analysis of theNetwork neuroscience (Cambridge, Mass.) · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kayvan BijariCenter for Neural Informatics, Structures, & Plasticity and Neuroscience Program, Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA.
Gema ValeraSensory Biology and Organogenesis, Helmholtz Zentrum Munich, 85764 Neuherberg, Germany.
Hernán López-SchierSensory Biology and Organogenesis, Helmholtz Zentrum Munich, 85764 Neuherberg, Germany.
Giorgio A AscoliCenter for Neural Informatics, Structures, & Plasticity and Neuroscience Program, Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA.
George Mason University · USHelmholtz Zentrum München · DE

Funding

Zooming into the fish's brain-What is really going on! Connectomics analysis of larval zebrafish.U19NS104653 · NINDS · HARVARD UNIVERSITY · PI Jeff W Lichtman · 2017 to 2026
$39.4M
Anatomical characterization of neuronal cell types of the mouse brainU01MH114829 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ASCOLI, GIORGIO A, DONG, HONG-WEI · 2017 to 2021
$13.9M
Generation and Description of Neuronal Morphology and ConnectivityR01NS039600 · NINDS · GEORGE MASON UNIVERSITY · PI ASCOLI, GIORGIO A · 1999 to 2024
$6.9M
Cytoskeletal mechanisms of dendrite arbor shape developmentR01NS086082 · NINDS · GEORGIA STATE UNIVERSITY · PI ASCOLI, GIORGIO A, COX, DANIEL N · 2013 to 2023
$3.1M
NIMH NIH HHS U01 MH114829NINDS NIH HHS R01 NS039600NINDS NIH HHS R01 NS086082NINDS NIH HHS U19 NS104653
6 · The paper itself

Abstract

We present a protocol to characterize the morphological properties of individual neurons reconstructed from microscopic imaging. We first describe a simple procedure to extract relevant morphological features from digital tracings of neural arbors. Then, we provide detailed steps on classification, clustering, and statistical analysis of the traced cells based on morphological features. We illustrate the pipeline design using specific examples from zebrafish anatomy. Our approach can be readily applied and generalized to the characterization of axonal, dendritic, or glial geometry. For complete context and scientific motivation for the studies and datasets used here, refer to Valera et al. (2021).

Indexed as

Machine LearningAnimalsImage Processing, Computer-AssistedMicroscopyNeuronsSoftwareZebrafishBioinformaticsCell BiologyComputer sciencesMicroscopyNeuroscience

Identifiers

PMID34647039
PMCPMC8496329
OpenAlexW3203920527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.