Evidence map›Paper›PMID 34646950›Full record

ArticleClinical and translational radiation oncology2021

Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL).

Jeremiah de Leon, Amanda Woods, Tania Twentyman, Michael Meade, Vicki Sproule, Smitha Chandran, Joseph Christiansen, Neil Kennedy, Maria Marney, Kris Barooshian and 8 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  8. Optimising the MR-Linac as a standard treatment modality.Journal of medical radiation sciences · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 3 countries.

Jeremiah de LeonGenesisCare, Sydney, Australia.
Amanda WoodsGenesisCare, Sydney, Australia.
Tania TwentymanGenesisCare, Sydney, Australia.
Michael MeadeGenesisCare, Sydney, Australia.
Vicki SprouleGenesisCare, Sydney, Australia.
Smitha ChandranGenesisCare, Sydney, Australia.
Joseph ChristiansenGenesisCare, Sydney, Australia.
Neil KennedyGenesisCare, Sydney, Australia.
Maria MarneyGenesisCare, Sydney, Australia.
Kris BarooshianGenesisCare, Sydney, Australia.
Michael PlitGenesisCare, Sydney, Australia.
Jayd LynchGenesisCare, Sydney, Australia.
Raj JagavkarGenesisCare, Sydney, Australia.
Helen OrmandyGenesisCare, Sydney, Australia.
John ChristodouleasElekta AB, Stockholm, Sweden.
Florian PietzschGenesisCare, Sydney, Australia.
Michael ChanGenesisCare, Sydney, Australia.
Michael G JamesonGenesisCare, Sydney, Australia.
Australian and New Zealand Intensive Care Society · AUUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnalysis of Data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) is a multi-site, multinational, observational cohort registry designed to collect data on the use of the magnetic resonance linear accelerator (MR-Linac) for radiation therapy and patient outcomes. The registry will provide a linked repository of technical and clinical data that will form a platform for prospective studies and technology assessment.

methodsDesign: This registry aims to include an estimated 10,000 eligible participants across Australia and other countries over a 7- to 10-year period. Participants will undergo treatment and assessments in accordance with standard practice. Toxicity and survival outcomes will be assessed at baseline, during treatment, and with 3 monthly follow-up until 24 months, patient reported outcome measures will also be collected. Participants with a variety of cancers will be included. DISCUSSION: Data obtained from the ADAPT-MRL registry is expected to provide evidence on the safety and efficacy of the MR-Linac, a new technical innovation in radiation oncology. We expect this registry will generate data that will be used to optimise treatment techniques, MR-Linac software algorithms, evaluate participants' outcomes and toxicities and to create a repository of adapted plans, anatomical and functional MR sequences linked to participants' outcomes.

Indexed as

ADAPT-MRLMRIMR-LinacRadiotherapyRegistry

Identifiers

PMID34646950
PMCPMC8495756
OpenAlexW3201396276

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.