ArticleNeurobiology of stress2021
Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task.
Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- Social reward processing in depressed and healthy individuals across the lifespan: A systematic review and a preliminary coordinate-based meta-analysis of fMRI studies.Behavioural brain research · 2023Pooled it
- The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies.Frontiers in psychiatry · 2023Pooled it
- Aberrant functional connectivity of the globus pallidus in the modulation of the relationship between childhood trauma and major depressive disorder.Journal of psychiatry & neuroscience : JPNTrial
- Brain network centrality following stress in adults with major depressive disorder and childhood trauma.Neurobiology of stress · 2026Article
- Putamen subregion dysfunction mediates the relationship between childhood maltreatment and major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Impaired emotional processing in insomnia: REM sleep beta power and frontal cortex activation.BMC medicine · 2025Article
- Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia.BMC medicine · 2025Article
- Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior.BMC psychiatry · 2025Article
- Hippocampal subfield and amygdala volumes are associated with difficulties in emotion regulation of depressed patients with a history of childhood maltreatment.Frontiers in psychiatry · 2025Article
- Emotional recognition technologies applied to health: review and challenges.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Review
- Altered dynamic functional connectivity of nucleus accumbens subregions in major depressive disorder: the interactive effect of childhood trauma and diagnosis.Social cognitive and affective neuroscience · 2024Article
- Early Life Stress and Major Depressive Disorder-An Update on Molecular Mechanisms and Synaptic Impairments.Molecular neurobiology · 2024Review
- Parental depression moderates the relationship between childhood maltreatment and the recognition of children expressions of emotions.Frontiers in psychiatry · 2024Article
- Exposure to Multicultural Context Affects Neural Response to Out-Group Faces: A Functional Magnetic Resonance Imaging Study.Sensors (Basel, Switzerland) · 2023Article
- Human emotion processing accuracy, negative biases, and fMRI activation are associated with childhood trauma.Frontiers in psychiatry · 2023Article
- Altered Reward Circuit Function Moderates the Relationship between Childhood Maltreatment and Depression Severity in Adolescents.Depression and anxiety · 2023Article
- Altered effective connectivity among face-processing systems in major depressive disorder.Journal of psychiatry & neuroscience : JPNArticle
- Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IMPORTANCE AND
objectivesChildhood adversity is a strong risk factor for the development of various psychopathologies including major depressive disorder (MDD). However, not all depressed patients experience early life trauma. Functional magnetic resonance imaging (fMRI) studies using facial emotion processing tasks have documented altered blood-oxygen-level-dependent (BOLD) responses in specific cortico-limbic networks both in MDD patients and in individuals with a history of childhood maltreatment (CM). Therefore, a history of maltreatment may represent a key modulating factor responsible for the altered processing of socio-affective stimuli. To test this hypothesis, we recruited MDD patients with and without of maltreatment history to study the long-term consequences of childhood trauma and examined the impact of CM on brain activity using a facial emotion recognition fMRI task.
methodsMDD patients with childhood maltreatment (MDD + CM,
resultsBoth MDD and MDD + CM patients displayed impaired accuracy to recognize sad faces. Analysis of brain activity revealed that MDD + CM patients had significantly reduced negative BOLD signals in their right accumbens, subcallosal cortex, and anterior paracingulate gyrus compared to controls. Furthermore, MDD + CM patients had a significantly increased negative BOLD response in their right precentral and postcentral gyri compared to controls. We found little difference between MDD and MDD + CM patients, except that MDD + CM patients had reduced negative BOLD response in their anterior paracingulate gyrus relative to the MDD group.
conclusionsOur present data provide evidence that depressed patients with a history of maltreatment are impaired in facial emotion recognition and that they display altered functioning of key reward-related fronto-striatal circuits during a facial emotion matching task.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.