Evidence map›Paper›PMID 34646889›Full record

ArticleJournal of immunology research2021

Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF-

Changzoon Chun, Xiaoyan Qi, Fen Wang, Kyle B Madrid, Lennon A Saldarriaga, Max R Fisch, Mark L Brantly, Gilbert R Upchurch, Zhihua Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Association of polymorphisms inOpen medicine (Warsaw, Poland) · 2024
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Changzoon ChunDivision of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL 32603, USA.
Xiaoyan QiDivision of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL 32603, USA.
Fen WangDivision of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL 32603, USA.
Kyle B MadridDivision of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL 32603, USA.
Lennon A SaldarriagaDivision of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL 32603, USA.
Max R FischDivision of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL 32603, USA.
Mark L BrantlyDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL 32603, USA.
Gilbert R UpchurchDivision of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL 32603, USA.
Zhihua JiangDivision of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL 32603, USA.ORCID https://orcid.org/0000-0001-8057-823X
University of Florida · US

Funding

Immune injury as a driver for the development of ascending aortic aneurysms and dissectionsR01HL153545 · NHLBI · UNIVERSITY OF FLORIDA · PI JIANG, ZHIHUA, UPCHURCH, GILBERT RIVERS · 2020 to 2023
$2.3M
Role of RNA-mediated danger signals in regulating TAAD developmentR01HL148019 · NHLBI · UNIVERSITY OF FLORIDA · PI JIANG, ZHIHUA, UPCHURCH, GILBERT RIVERS · 2019 to 2022
$1.8M
NHLBI NIH HHS R01 HL148019NHLBI NIH HHS R01 HL153545
6 · The paper itself

Abstract

Tobacco smoke is an established risk factor for thoracic aortic aneurysms and dissections (TAAD). However, little is known about its underlying mechanisms due to the lack of validated animal models. The present study developed a mouse model that may be utilized to investigate exacerbation of TAAD formation by mimetics of tobacco smoke. TAADs were created via inducible deletion of smooth muscle cell-specific

Indexed as

AnimalsAorta, ThoracicAortic Aneurysm, ThoracicAortic DissectionCigarette SmokingDisease Models, AnimalHumansMaleMiceMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNicotineReceptor, Transforming Growth Factor-beta Type IINicotineReceptor, Transforming Growth Factor-beta Type IITgfbr2 protein, mouse

Identifiers

PMID34646889
PMCPMC8505064
OpenAlexW3203738879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.