Evidence map›Paper›PMID 34646861›Full record

ArticleFrontiers in molecular biosciences2021

Synergy Between Beta-Lactams and Lipo-, Glyco-, and Lipoglycopeptides, Is Independent of the Seesaw Effect in Methicillin-Resistant

Rutan Zhang, Ismael A Barreras Beltran, Nathaniel K Ashford, Kelsi Penewit, Adam Waalkes, Elizabeth A Holmes, Kelly M Hines, Stephen J Salipante, Libin Xu, Brian J Werth

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Antibiotic synergy againstAntimicrobial agents and chemotherapy · 2025
    Pooled it
  2. Genomic investigation and clinical correlates of theAntimicrobial agents and chemotherapy · 2024
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A rapid single-phase extraction for polar staphylococcal lipids.Analytical and bioanalytical chemistry · 2023
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Rutan ZhangDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, United States.
Ismael A Barreras BeltranDepartment of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA, United States.
Nathaniel K AshfordDepartment of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA, United States.
Kelsi PenewitDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States.
Adam WaalkesDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States.
Elizabeth A HolmesDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States.
Kelly M HinesDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, United States.
Stephen J SalipanteDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States.
Libin XuDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, United States.
Brian J WerthDepartment of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA, United States.
University of Washington · US

Funding

Contribution of altered lipid metabolism to resistance to cell envelope-targeting antimicrobials in MRSAR01AI136979 · NIAID · UNIVERSITY OF WASHINGTON · PI Brian James Werth, Libin Xu · 2018 to 2026
$4.1M
Resistance Selection Potential of the Long Acting Lipoglycopeptides Dalbavancin and OritavancinR21AI132994 · NIAID · UNIVERSITY OF WASHINGTON · PI WERTH, BRIAN JAMES · 2018 to 2019
$428k
NIAID NIH HHS R01 AI136979NIAID NIH HHS R21 AI132994
6 · The paper itself

Abstract

Methicillin-resistant

Indexed as

beta-lactam antibacterialsdalbavancindaptomycinlipidomic analysismembrane fluidityseesaw effectsynergyvancomycin

Identifiers

PMID34646861
PMCPMC8503943
OpenAlexW3200304787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.