Evidence map›Paper›PMID 34646841›Full record

ArticleFrontiers in medicine2021

Therapeutic Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Recovering From Murine Pulmonary Emphysema Under Cigarette Smoke Exposure.

Xiao-Yue Chen, Yi-Ying Chen, Willie Lin, Chien-Han Chen, Yu-Chieh Wen, Ta-Chih Hsiao, Hsiu-Chu Chou, Kian Fan Chung, Hsiao-Chi Chuang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Stem cell-based therapy for human diseases.Signal transduction and targeted therapy · 2022
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Xiao-Yue ChenGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yi-Ying ChenSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Willie LinMeridigen Biotech Co., Ltd., Taipei, Taiwan.
Chien-Han ChenMeridigen Biotech Co., Ltd., Taipei, Taiwan.
Yu-Chieh WenMeridigen Biotech Co., Ltd., Taipei, Taiwan.
Ta-Chih HsiaoGraduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan.
Hsiu-Chu ChouDepartment of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Hsiao-Chi ChuangSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Taipei Medical University · TWImperial College London · GBNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) were shown to have potential for immunoregulation and tissue repair. The objective of this study was to investigate the effects of hUC-MSCs on emphysema in chronic obstructive pulmonary disease (COPD). The C57BL/6JNarl mice were exposed to cigarette smoke (CS) for 4 months followed by administration of hUC-MSCs at 3 × 10

Indexed as

cigarette smokeCOPDemphysemainflammationstem cell

Identifiers

PMID34646841
PMCPMC8502916
OpenAlexW3202868060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.