Evidence map›Paper›PMID 34646818›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Antibacterial Peptide HHC-36 Sustained-Release Coating Promotes Antibacterial Property of Percutaneous Implant.

Qiang Miao, Jin-Long Sun, Fei Huang, Jing Wang, Pei Wang, Ya-Fei Zheng, Feng Wang, Chu-Fan Ma

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qiang MiaoDepartment of Stomatology, Sixth Medical Center of PLA General Hospital, Beijing, China.
Jin-Long SunDepartment of Stomatology, Sixth Medical Center of PLA General Hospital, Beijing, China.
Fei HuangDepartment of Stomatology, Sixth Medical Center of PLA General Hospital, Beijing, China.
Jing WangAir Force Medical Center, The Fourth Military Medical University, Beijing, China.
Pei WangDepartment of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Wendeng, China.
Ya-Fei ZhengState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Feng WangDepartment of Stomatology, Sixth Medical Center of PLA General Hospital, Beijing, China.
Chu-Fan MaState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Chinese PLA General Hospital · CNAir Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Percutaneous implants are widely used in clinical practice. However, infection is the main clinical problem of percutaneous implants. Titanium dioxide nanotubes are suitable for forming coatings on complex surfaces such as implants. HHC-36, a cationic antimicrobial peptide, has been identified to have a strong broad-spectrum antibacterial effect. In the present study, we use poly D,L-lactic acid (PDLLA) and poly lactic-co-glycolic acid (PLGA) coating to build HHC-36 sustained-release system on the surface of titanium dioxide nanotubes. The titanium specimens were anodized coated with HHC-36-PDLLA/PLGA. The morphology and surface elemental distribution of the specimens were evaluated. Besides, results in the present study demonstrated that with antibacterial peptide HHC-36 sustained-release coating, titanium dioxide nanotubes maintain effective drug release for 15 days

Indexed as

antibacterial peptideantibacterial propertyHHC-36percutaneous implanttitanium dioxide nanotube (TNT)

Identifiers

PMID34646818
PMCPMC8503604
OpenAlexW3201921099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.