ArticleFrontiers in cellular and infection microbiology2021
Metagenomic Analysis of Saliva Reveals Disease-Associated Microbiotas in Patients With Periodontitis and Crohn's Disease-Associated Periodontitis.
Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- The redefined identity ofJournal of bacteriology · 2026Review
- Metagenomics in the Interplay Among Oral and Gut Dysbiosis.Metabolites · 2026Review
- Oral-Gut Microbial Crosstalk and Therapeutic Applications of Bacterial Extracellular Vesicles.Biomolecules · 2025Review
- In-Depth Multi-Approach Analysis of WGS Metagenomics Data Reveals Signatures Potentially Explaining Features in Periodontitis Stage Severity.Dentistry journal · 2025Article
- Advances in pH-responsive drug delivery systems for periodontitis treatment.Drug delivery · 2025Review
- Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer.JAMA oncology · 2025Article
- Salivary microbiota dysbiosis and elevated polyamine levels contribute to the severity of periodontal disease.BMC oral health · 2025Article
- Article
- Bacterial microbiome profiles of the inflamed terminal ileum mucosa in active Crohn's disease patients.PeerJ · 2025Article
- Salivary microbiota profile in adult and children population according to active dentin caries: a metagenomic preliminary analysis.Frontiers in oral health · 2025Article
- Unravelling the Oral-Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective.Journal of Crohn's & colitis · 2024Review
- Causal Association Analysis of Periodontitis and Inflammatory Bowel Disease: A Bidirectional Mendelian Randomization Study.Inflammatory bowel diseases · 2024Article
- The oral-gut microbiome axis in inflammatory bowel disease: from inside to insight.Frontiers in immunology · 2024Review
- The involvement of oral bacteria in inflammatory bowel disease.Gastroenterology report · 2024Review
- Deciphering salivary microbiome signature in Crohn's disease patients with different factors contributing to dysbiosis.Scientific reports · 2023Article
- Oral Manifestations of Crohn's Disease: A Systematic Review.Journal of clinical medicine · 2023Review
- Association between lipid metabolism and periodontitis in obese patients: a cross-sectional study.BMC endocrine disorders · 2023Article
- The oral microbiome in autoimmune diseases: friend or foe?Journal of translational medicine · 2023Review
- Characterizing the microbiota of cleft lip and palate patients: a comprehensive review.Frontiers in cellular and infection microbiology · 2023Review
- Gut-microbiota-brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence.European archives of psychiatry and clinical neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Crohn's disease frequently develop oral health problems and show a higher prevalence of oral manifestations, such as dental caries and periodontitis, than healthy individuals do. In this study, a metagenomic analysis was carried out to characterize the salivary microbiota in patients with either periodontitis or Crohn's disease-associated periodontitis. Saliva samples were collected from six patients with both Crohn's disease and periodontitis (Cm group), six patients with periodontitis alone (Pm group), and six healthy individuals (Hm group). Genomic DNA was collected from these samples for high-throughput Illumina HiSeq metagenomic sequencing. The composition of the bacterial communities and their metabolic pathways and gene functions were characterized and compared among the three study groups. The salivary microbial communities were significantly different among the three groups, with Firmicutes, Actinobacteria, and Bacteroidetes showing the most significant differences. The Cm and Pm groups had higher abundances of
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