ArticleFrontiers in oncology2021
Bone Metastases of Glioblastoma: A Case Report and Review of the Literature.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Prognostic nomogram for glioblastoma (GBM) patients presenting with distant extension: a seer-based study.Journal of cancer research and clinical oncology · 2023Trial
- Early extracranial dissemination with prolonged survival in IDH-wildtype glioblastoma: case study and comprehensive literature review.CNS oncology · 2026Review
- High-grade glioma with dural progression: A single-center case series and review of literature.Radiology case reports · 2026Article
- Cell therapies against brain tumors: Clinical development and emerging prospects.Bioengineering & translational medicine · 2025Review
- Rapidly progressive scalp and lung metastases with fatal pneumothorax in glioblastoma, IDH-wildtype, with MET and CDK6 amplifications: a case report of clinical course and postmortem autopsy, including genetic analysis.Brain tumor pathology · 2025Article
- Clinical and Imaging Features of Head and Neck Metastasis of High-Grade Glioma: A Single-Center Case Series.AJNR. American journal of neuroradiology · 2025Article
- Pleomorphic xanthoastrocytoma with multiple recurrences and continuous malignant progression to bone metastasis: a case report.Frontiers in surgery · 2025Article
- Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers.Ibrain · 2025Review
- Extraneural metastases of glioblastoma: A case report and literature review.Surgical neurology international · 2025Article
- Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review.Oncology letters · 2024Article
- Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.Cancer reports (Hoboken, N.J.) · 2023Review
- Letter to the editor regarding "unusual extraneural metastasis of glioblastoma".Surgical neurology international · 2023Article
- Unusual extraneural metastasis of glioblastoma.Surgical neurology international · 2023Article
- Recurrent glioblastoma metastatic to the lumbar vertebra: A case report and literature review: Surgical oncology.Frontiers in oncology · 2023Article
- Intracranial dissemination of glioblastoma multiforme: a case report and literature review.The Journal of international medical research · 2022Review
- Article
- Glioblastoma multiforme with vertebral metastases: A case report.CNS neuroscience & therapeutics · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlioblastoma (GBM) is the most common primary intracranial tumor and originates from the small pool of adult neural stem and progenitor cells (NSPCs). According to the World Health Organization (WHO) classification of brain tumors, gliomas are classified into grades I-IV, and GBM is defined as the highest grade (IV). GBM can be disseminated by cerebrospinal fluid (CSF), but extracranial metastasis is rare. Additionally, the pathway and mechanism involved remain unclear. CASE PRESENTATION: We report a rare case of left temporal lobe GBM with multiple bone metastases and soft tissue metastasis. This 49-year-old right-handed man who was diagnosed with GBM underwent surgery on May 9, 2017, followed by radiochemotherapy in June 2017. On August 13, 2019, local relapse was found. Then, the patient received a second surgery but not radiochemotherapy. In November 2019, the patient was reported to be suffering from low back pain for nearly 1 month. On December 6, 2019, magnetic resonance imaging (MRI) of the thoracolumbar vertebrae and abdominal computed tomography (CT) confirmed metastases on the ninth posterior rib on the right, the third anterior rib on the left, and the T7 and T10 vertebrae and their appendages. CT-guided rib space-occupying puncture biopsy was performed, and GBM was identified by pathology.
conclusionWe should pay attention to extracranial metastasis of GBM. Timely detection and early treatment improve overall quality of patients' life. The extracranial metastasis in this patient may have occurred through the spinal nerve root or intercostal nerve. Further clinical observations are required to clarify the pathway and mechanism involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.