Evidence map›Paper›PMID 34646658›Full record

ArticleCureus2021

Early-Onset Parkinson's Disease With Multiple Positive Intraoperative Spinal Tissue Cultures for Cutibacterium acnes.

Mervat Mourad, Tija M Passley, John M Purcell, Joerg R Leheste

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mervat MouradClinical Specialties, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, USA.
Tija M PassleyBasic Sciences, New York Institute of Technology College of Osteopathic Medicine, Jonesboro, USA.
John M PurcellBasic Sciences, New York Institute of Technology College of Osteopathic Medicine, Jonesboro, USA.
Joerg R LehesteBiomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, USA.
Philadelphia College of Osteopathic Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An estimated 95-97% of Parkinson's disease (PD) cases are idiopathic, emphasizing the absence of a clear etiologic linkage for this debilitating, neurodegenerative, and progressive motor disease. Increasing evidence suggests a peripheral disease origin and the gradual transition of a pathological process along the gut-brain axis and olfactory routes into the brain. This disease pattern is reminiscent of an infectious process and suggests the presence of one or multiple infectious agents, such as bacteria, viruses, fungi, or prion-like proteins. This unusual paradigm, known as Braak's hypothesis, was first described by the scientist who developed the staging standard for cellular PD pathology and. Here, we describe a case where the small, anaerobic, Gram-positive

Indexed as

braak’s hypothesiscutibacterium acneslymphatic pumpneuroinflammationparkinson’s disease

Identifiers

PMID34646658
PMCPMC8483448
OpenAlexW3197366128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.