Evidence map›Paper›PMID 34646580›Full record

ArticleNeurology research international2021

Myelin Basic Protein and Cardiac Sympathetic Neurodegeneration in Nonhuman Primates.

Jeanette M Metzger, Helen N Matsoff, Don Vu, Alexandra D Zinnen, Kathryn M Jones, Viktoriya Bondarenko, Heather A Simmons, Colleen F Moore, Marina E Emborg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Glia of the heart's nervous system.Nature reviews. Neuroscience · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeanette M MetzgerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Helen N MatsoffWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Don VuWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Alexandra D ZinnenWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Kathryn M JonesWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Viktoriya BondarenkoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Heather A SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Colleen F MooreDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53715, USA.
Marina E EmborgWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.ORCID https://orcid.org/0000-0002-9351-6641

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
EXTRAMURAL RES FACIL CONST: REPRODUCTIVE, GROWTH &DVMT, MENOPAUSEC06RR020141 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2004 to 2004
$3.6M
EXTRAMURAL REGIONAL FACILITIES CONSTRUCTIONC06RR015459 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2000 to 2000
$1.9M
Activation of PPAR-gamma in a Monkey Model of Cardiac DysautonomiaR21NS084158 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI EMBORG, MARINA · 2014 to 2015
$406k
ncRNAs and PPARy-Induced Sympathetic Neuroprotection in an NHP Model of Cardiac NeurodegenerationF31HL136047 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI METZGER, JEANETTE · 2017 to 2018
$63k
NCRR NIH HHS C06 RR015459NCRR NIH HHS C06 RR020141NHLBI NIH HHS F31 HL136047NIH HHS P51 OD011106NINDS NIH HHS R21 NS084158
6 · The paper itself

Abstract

Minimal myelination is proposed to be a contributing factor to the preferential nigral neuronal loss in Parkinson's disease (PD). Similar to nigral dopaminergic neurons, sympathetic neurons innervating the heart have long, thin axons which are unmyelinated or minimally myelinated. Interestingly, cardiac sympathetic loss in PD is heterogeneous across the heart, yet the spatial relationship between myelination and neurodegeneration is unknown. Here, we report the mapping of myelin basic protein (MBP) expression across the left ventricle of normal rhesus macaques (

Identifiers

PMID34646580
PMCPMC8505074

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.