Evidence map›Paper›PMID 34646429›Full record

ArticleInternational IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering2021

The effect of axon trajectory on retinal ganglion cell activation with epiretinal stimulation.

Kathleen E Kish, Robert D Graham, Kwoon Y Wong, James D Weiland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kathleen E KishDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA and are associated with the Biointerfaces Institute.
Robert D GrahamDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA and are associated with the Biointerfaces Institute.
Kwoon Y WongDepartment of Ophthalmology and Visual Sciences.
James D WeilandDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA and are associated with the Biointerfaces Institute.

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
NEI NIH HHS P30 EY007003
6 · The paper itself

Abstract

For epiretinal prostheses, disc electrodes stimulate retinal ganglion cells (RGCs) with electric current to create visual percepts. Prior studies have determined that the sodium channel band (SOCB), located on the RGC axon (30-50 μm from the soma) is the most sensitive site to extracellular stimulation because of its high sodium channel density. Biophysical cable models used to study RGC activation

Identifiers

PMID34646429
PMCPMC8510560

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.