Evidence map›Paper›PMID 34646422›Full record

ArticleOxidative medicine and cellular longevity2021

Beta3-Adrenergic Receptor Activation Alleviates Cardiac Dysfunction in Cardiac Hypertrophy by Regulating Oxidative Stress.

Mingming Zhang, Yuerong Xu, Jianghong Chen, Chaoshi Qin, Jing Liu, Dong Guo, Rui Wang, Jianqiang Hu, Qing Zou, Jingxiao Yang and 2 more

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Effects of Ranolazine on Vascular Adrenergic Receptors in Rabbit Aorta.International journal of medical sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Mingming ZhangDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.ORCID https://orcid.org/0000-0001-8480-0280
Yuerong XuDepartment of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Jianghong ChenDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Chaoshi QinDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Jing LiuDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Dong GuoDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Rui WangDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Jianqiang HuDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Qing ZouDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Jingxiao YangDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Zikuan WangDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Xiaolin NiuDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.ORCID https://orcid.org/0000-0002-8320-5516
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExcessive myocardial oxidative stress could lead to the congestive heart failure. NADPH oxidase is involved in the pathological process of left ventricular (LV) remodeling and dysfunction.

methodsCardiac hypertrophy was constructed by the transverse aortic constriction (TAC) model. ROS and NADPH oxidase subunits expression were assessed after

results

conclusion

Indexed as

Adrenergic beta-AgonistsAnimalsCardiomegalyMiceMice, Inbred C57BLMyocardiumMyocytes, CardiacOxidative StressReactive Oxygen SpeciesReceptors, Adrenergic, beta-3Ventricular RemodelingAdrenergic beta-AgonistsReactive Oxygen SpeciesReceptors, Adrenergic, beta-3

Identifiers

PMID34646422
PMCPMC8505079
OpenAlexW3203367762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.