Evidence map›Paper›PMID 34646386›Full record

ArticleTheranostics2021

Effects of contrast-enhanced ultrasound treatment on neoadjuvant chemotherapy in breast cancer.

Anne Rix, Marion Piepenbrock, Barbara Flege, Saskia von Stillfried, Patrick Koczera, Tatjana Opacic, Nina Simons, Peter Boor, Sven Thoröe-Boveleth, Roel Deckers and 5 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 49 citations in OpenAlex.

  1. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
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  5. Sonopermeation combined with stroma normalization enables complete cure using nano-immunotherapy in murine breast tumors.Journal of controlled release : official journal of the Controlled Release Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Anne RixInstitute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Marion PiepenbrockChair for Medical Engineering, Department of Electrical Engineering and Information Technology, Ruhr University Bochum, Bochum, Germany.
Barbara FlegeDepartment of Obstetrics and Gynecology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Saskia von StillfriedInstitute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Patrick KoczeraInstitute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Tatjana OpacicInstitute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Nina SimonsDepartment of Obstetrics and Gynecology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Peter BoorInstitute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Sven Thoröe-BovelethInstitute for Occupational, Social and Environmental Medicine; Medical Faculty, RWTH Aachen University, Aachen, Germany.
Roel DeckersDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Jan-Niklas MayInstitute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Twan LammersInstitute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Georg SchmitzChair for Medical Engineering, Department of Electrical Engineering and Information Technology, Ruhr University Bochum, Bochum, Germany.
Elmar StickelerDepartment of Obstetrics and Gynecology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Fabian KiesslingInstitute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany.
RWTH Aachen University · DEUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAnimalsBreast NeoplasmsCarboplatinContrast MediaFemaleHumansMiceMice, Inbred BALB CMicrobubblesMiddle AgedNeoadjuvant TherapyPerfusionProspective StudiesTriple Negative Breast NeoplasmsUltrasonic TherapyCarboplatinContrast Mediabreast cancerCEUSchemotherapysonopermeationsuper-resolution ultrasound

Identifiers

PMID34646386
PMCPMC8490514
OpenAlexW3207861839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.