ArticleTheranostics2021
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.
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Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Tryptophan metabolism: A hidden regulator of female reproductive health beyond fertility.Chinese medical journal · 2026Review
- Nexus of IDO1/Kynurenine Pathway to T-Cell Exhaustion: Hypoxia-Induced Tryptophan Metabolism in Glioblastoma.Metabolites · 2026Review
- Gut microbiota and glioblastoma: composition, mechanisms, and therapeutic interventions.Infectious agents and cancer · 2026Review
- Reimagining AHR in Cancer: From Environmental Sensor to Novel Immunomodulatory Therapeutic Target.International journal of biological sciences · 2026Review
- Single-Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tryptophan metabolism in tumor immune escape: mechanisms, cellular crosstalk, and therapeutic opportunities.Frontiers in immunology · 2026Review
- Glioblastoma metabolomics: uncovering biomarkers for diagnosis, prognosis and targeted therapy.Journal of experimental & clinical cancer research : CR · 2025Review
- Tryptophan metabolism: From physiological functions to key roles and therapeutic targets in cancer (Review).Oncology reports · 2025Review
- Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma.Cell proliferation · 2025Article
- Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis.BJC reports · 2025Article
- Amino acid metabolism in glioblastoma pathogenesis, immune evasion, and treatment resistance.Cancer cell international · 2025Review
- Targeting the Kynurenine Pathway: A Novel Approach in Tumor Therapy.Expert reviews in molecular medicine · 2025Review
- The Impact of Metabolic Rewiring in Glioblastoma: The Immune Landscape and Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Preoperative Peripheral Blood Serotonin and Kynurenine Levels Are Associated With Oncological Outcomes in Glioblastoma IDH-wt Patients.International journal of tryptophan research : IJTR · 2025Article
- Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis.Biology direct · 2024Article
- Unveiling tryptophan dynamics and functions across model organisms via quantitative imaging.BMC biology · 2024Article
- Modulation of the Immune Environment in Glioblastoma by the Gut Microbiota.Biomedicines · 2024Review
- Interplay between gut microbiota and tryptophan metabolism in type 2 diabetic mice treated with metformin.Microbiology spectrum · 2024Article
- Article
- Glioblastoma Therapy: Past, Present and Future.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
28 authors at 5 institutions in 2 countries.
Verena PanitzDKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Saša KončarevićProteome Sciences R&D GmbH & Co. KG, Altenhöferallee 3, 60438 Frankfurt/Main, Germany.
Ahmed SadikDKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Dennis FriedelDKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Tobias BausbacherCenter for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
Saskia TrumpMolecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.
Vadim FarztdinovProteome Sciences R&D GmbH & Co. KG, Altenhöferallee 3, 60438 Frankfurt/Main, Germany.
Sandra SchulzCenter for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
Philipp SieversDepartment of Neuropathology, Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Stefan SchmidtCenter for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
Ina JürgensonDKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Stephan JungProteome Sciences R&D GmbH & Co. KG, Altenhöferallee 3, 60438 Frankfurt/Main, Germany.
Karsten KuhnProteome Sciences R&D GmbH & Co. KG, Altenhöferallee 3, 60438 Frankfurt/Main, Germany.
Irada PflügerDepartment of Neuroradiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Suraj SharmaDepartment of Arctic and Marine Biology, UiT, The Arctic University of Norway, 9037 Tromsø, Norway.
Antje WickDepartment of Neurology and National Center for Tumor Diseases, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Pauline PfänderDKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Stefan SelzerProteome Sciences R&D GmbH & Co. KG, Altenhöferallee 3, 60438 Frankfurt/Main, Germany.
Philipp VollmuthDepartment of Neuroradiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Felix SahmDepartment of Neuropathology, Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Andreas von DeimlingDepartment of Neuropathology, Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Ines HeilandDepartment of Arctic and Marine Biology, UiT, The Arctic University of Norway, 9037 Tromsø, Norway.
Carsten HopfCenter for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
Peter Schulz-KnappeProteome Sciences R&D GmbH & Co. KG, Altenhöferallee 3, 60438 Frankfurt/Main, Germany.
Ian PikeProteome Sciences plc, 5 Dashwood Lang Road, Bourne Business Park, Addlestone, Surrey KT15 2HJ, United Kingdom.
Michael PlattenDepartment of Neurology, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Wolfgang WickDepartment of Neurology and National Center for Tumor Diseases, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Christiane A OpitzDKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Heidelberg University · DEGerman Cancer Research Center · DEMannheim University of Applied Sciences · DEUniversity Hospital Heidelberg · DEUiT The Arctic University of Norway · NO
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tryptophan (Trp)-catabolic enzymes (TCEs) produce metabolites that activate the aryl hydrocarbon receptor (AHR) and promote tumor progression and immunosuppression in glioblastoma. As therapies targeting TCEs or AHR become available, a better understanding of Trp metabolism is required.
Indexed as
Cell Line, TumorChromatography, LiquidCohort StudiesDatabases, GeneticFemaleGlioblastomaHumansImmunotherapyMaleMiddle AgedReceptors, Aryl HydrocarbonTandem Mass SpectrometryTryptophanReceptors, Aryl HydrocarbonTryptophanAHRGlioblastomaMALDI MSImass spectrometrytryptophan
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.