Evidence map›Paper›PMID 34646277›Full record

ArticleFrontiers in immunology2021

The Era of Antimicrobial Peptides: Use of Hepcidins to Prevent or Treat Bacterial Infections and Iron Disorders.

Carolina Barroso, Pedro Carvalho, Magda Nunes, José F M Gonçalves, Pedro N S Rodrigues, João V Neves

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
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  7. Review
  8. Review
  9. Article
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  12. Animal models of kidney iron overload and ferroptosis: a review of the literature.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Immune Modulation Ability of Hepcidin from Teleost Fish.Animals : an open access journal from MDPI · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Carolina Barrosoi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Pedro CarvalhoICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Magda NunesICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
José F M GonçalvesICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Pedro N S Rodriguesi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
João V Nevesi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Universidade do Porto · PTi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic agents, with vaccines being available for a limited number of fish species and pathogens. Antimicrobial peptides are considered as promising novel substances to be used in aquaculture, due to their antimicrobial and immunomodulatory activities. Hepcidin, the major iron metabolism regulator, is found as a single gene in most mammals, but in certain fish species, including the European sea bass (

Indexed as

PhotobacteriumAmino Acid SequenceAnimalsAntimicrobial PeptidesApoferritinsBacterial LoadBassCation Transport ProteinsFerroportinFish DiseasesGene Expression ProfilingGram-Negative Bacterial InfectionsHepcidinsIronIron OverloadLiverAntimicrobial PeptidesApoferritinsCation Transport ProteinsFerroportinHepcidinsIronSolute Carrier Family 11, Member 2antimicrobial peptidesaquacultureEuropean sea bass (Dicentrarchus labrax)hepcidininfectioniron homeostasis

Identifiers

PMID34646277
PMCPMC8502971
OpenAlexW3201820800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.