Evidence map›Paper›PMID 34646113›Full record

ArticleFrontiers in neuroscience2021

Electroacupuncture Improves M2 Microglia Polarization and Glia Anti-inflammation of Hippocampus in Alzheimer's Disease.

Lushuang Xie, Yi Liu, Ning Zhang, Chenyu Li, Aaron F Sandhu, George Williams, Yan Shen, Hongying Li, Qiaofeng Wu, Shuguang Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 8 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 8 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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  18. (Ba,Ca)(Ti,Sn)OFrontiers in cellular neuroscience · 2026
    Article
  19. Review
  20. Electroacupuncture alleviates Parkinson's disease-related pain by inhibiting microglial NLRP3-ASC inflammasome in the amygdala.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Lushuang XieCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yi LiuDepartment of Neurology, Dalian Municipal Central Hospital, Affiliated Hospital of Dalian Medical University, Dalian, China.
Ning ZhangElectroacupuncture and Moxibustion College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chenyu LiElectroacupuncture and Moxibustion College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Aaron F SandhuDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
George WilliamsDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Yan ShenElectroacupuncture and Moxibustion College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hongying LiElectroacupuncture and Moxibustion College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Qiaofeng WuInstitute of Electroacupuncture and Homeostasis Regulation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Shuguang YuInstitute of Electroacupuncture and Homeostasis Regulation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chengdu University of Traditional Chinese Medicine · CNHarvard University · USDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acupunctureAlzheimer’s diseaseastrocytecytokinesmicroglia

Identifiers

PMID34646113
PMCPMC8502881
OpenAlexW3202817066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.