ReviewAmerican journal of lifestyle medicine
Loneliness and Social Isolation as Risk Factors: The Power of Social Connection in Prevention.
Review in American journal of lifestyle medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06987708 (Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance), which is not on this map. Cited by 84 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance (MGUS) and Smoldering Myeloma (SM): A Prospective Intervention Pilot Study
Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Loneliness without an epidemic: gendered pathways, health consequences, and intervention gaps among men in the United States.Frontiers in public health · 2026Pooled it
- A systematic review of how social connectedness influences associations between racism and discrimination on health outcomes.Epidemiologic reviews · 2023Pooled it
- Groups for belonging: a parallel cluster randomized controlled trial of a group-based loneliness intervention for people attending treatment for alcohol and other drug use.BMC public health · 2025Trial
- Supportive-leadership training to improve social connection: A cluster-randomized trial demonstrating efficacy in a high-risk occupational context.Journal of occupational health psychology · 2024Trial
- The impact of loneliness and social isolation on the benefits of an exercise program with hospitalised older adults.The journal of nutrition, health & aging · 2024Trial
- Exploring General Practice Nurses' Experiences of an Intervention to Support Social Connectedness Among Older Adults: A Qualitative Descriptive Study.Journal of clinical nursing · 2026Article
- Feasibility of Using a Wearable Device to Identify Loneliness Among Older Adults Living Alone: Mixed Methods Study.JMIR formative research · 2026Article
- Artificial Intelligence as Companionship: A Systemic and Relational Examination Using Empirical Data From Psyhelp.Journal of marital and family therapy · 2026Article
- Article
- Perceived Social Connectedness and Substance Use among Adolescents and Young Adults in North Carolina.Prevention science : the official journal of the Society for Prevention Research · 2026Article
- Determinants of empathy, depression and loneliness in Serbian medical students.Discover mental health · 2026Article
- The Association Between Negative Emotion and Suicidal Ideation in Chinese Migrant Workers: A Chain Mediation Model of Meaning in Life and Social Connectedness.Behavioral sciences (Basel, Switzerland) · 2026Article
- Species Extinction, Biodiversity, Human Health, and Inevitable Role of Lifestyle Medicine: A Narrative Review.American journal of lifestyle medicine · 2026Review
- Lifecourse socioeconomic status and subjective cognitive decline among diverse older adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Examining associations of social disconnectedness change patterns with subsequent healthcare utilization and costs among public healthcare users in Central Singapore.Scientific reports · 2026Article
- The Effects of Open-World and Fun, Accessible Games on Perceived Loneliness and Stoicism in Adults: Cross-Sectional Survey Study.JMIR serious games · 2026Article
- Prevalence of Loneliness and Social Isolation by Demographic, Socioeconomic, and Other Factors: Estimates From the 2024 Household Pulse Survey.Community mental health journal · 2026Article
- Listening to a Consonant Chord Progression during Live Face-to-Face Gaze Enhances Neural Activity in Social Systems.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Loneliness, social isolation, and health-related quality of life in older adults.European journal of ageing · 2026Article
- Social connections are differentially related to subjective age and physiological age acceleration amongst older adults.Nature communications · 2026Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social isolation and loneliness were already pressing concerns prior to the pandemic, but recent trends suggest a potential broadening of this public health crisis. Social connections have potent influences on health and longevity, and lacking social connection qualifies as a risk factor for premature mortality. However, social factors are often overlooked in medical and healthcare practice. There is also evidence documenting effects on biomarkers and health-relevant behaviors, as well as more proximal means social connection influences physical health. A recent National Academy of Science consensus committee report provides recommendations for how this evidence can inform medical and healthcare. Clinicians play an important role in assessing, preventing, and mitigating the adverse effects of social isolation and loneliness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.