ArticleNature2021
An endogenous opioid circuit determines state-dependent reward consumption.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 101 citations in OpenAlex.
- Differences in ethanol drinking and nucleus accumbens opioid expression in male and female obesity-prone and obesity-resistant rats.Alcohol (Fayetteville, N.Y.) · 2026Article
- Article
- Dorsal raphe nucleus enkephalin peptide modulates behavioral preference.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Serum Endogenous Opioid Levels are Associated with Self-Injury Severity in Adolescents with Non-Suicidal Self-Injury and Comorbid Depression.Neuroscience bulletin · 2026Article
- Xylazine potentiates the interoceptive effects of fentanyl in male and female rats.Psychopharmacology · 2026Article
- Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators.bioRxiv : the preprint server for biology · 2026Article
- Exercise modulates food reward: neurobiological mechanisms and implications for weight management.Frontiers in nutrition · 2026Review
- Article
- Characteristics of striatal changes in diabetic retinopathy and type 2 diabetes: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2026Article
- Down-regulation of gastrin-releasing peptide in medial orbitofrontal cortex to nucleus accumbens projections contributes to allodynia and negative affect.Science advances · 2025Article
- Article
- The neural circuits and signalling pathways of opioid use disorder.Nature reviews. Neuroscience · 2025Review
- Complex opioid driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward and addiction.bioRxiv : the preprint server for biology · 2025Article
- A nociceptive amygdala-striatal pathway modulating affective-motivational pain.Science advances · 2025Article
- Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice.eLife · 2025Article
- An Alternative Gene Editing Strategy Using a Single AAV Vector.Bio-protocol · 2025Article
- Article
- Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice.Acta pharmacologica Sinica · 2025Article
- Endogenous opioids and the development of the mammalian respiratory control network.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- Opioid Regulation of Social Homeostasis: Connecting Loneliness to Addiction.Biological psychiatry · 2025Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Daniel C CastroDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA. dcastro6@uw.edu.ORCID http://orcid.org/0000-0001-8036-1313
Corinna S OswellDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Eric T ZhangCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.
Christian E PedersenCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.
Sean C PiantadosiDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Mark A RossiDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Avery C HunkerCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.
Anthony GuglinDepartments of Anesthesiology, Neuroscience and Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Jose A MorónDepartments of Anesthesiology, Neuroscience and Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Larry S ZweifelCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3465-5331
Garret D StuberDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1730-4855
Michael R BruchasDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA. mbruchas@uw.edu.ORCID http://orcid.org/0000-0003-4713-7816
University of Washington · USWashington University in St. Louis · US
Funding
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0MNeural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5MNERVOUS SYSTEM DEVELOPMENT AND INJURYT32NS007205 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 1985 to 2017
$4.2MLateral Hypothalamic Circuits for Feeding and ReinforcementR01DA038168 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2014 to 2025
$4.0MDISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER37DA033396 · NIDA · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2018 to 2026
$3.8MDissecting circuits mediating pain-induced alterations in motivated behaviorR01DA041781 · NIDA · WASHINGTON UNIVERSITY · PI MORON-CONCEPCION, JOSE A · 2017 to 2021
$2.3MRole of SK2 channels in morphine dependenceR01DA042499 · NIDA · WASHINGTON UNIVERSITY · PI MORON-CONCEPCION, JOSE A · 2017 to 2021
$1.9MDISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER01DA033396 · NIDA · WASHINGTON UNIVERSITY · PI BRUCHAS, MICHAEL R. · 2013 to 2017
$1.9MDefining a role for kappa opioid system in affective behavior and drug escalation in painR01DA045463 · NIDA · WASHINGTON UNIVERSITY · PI MORON-CONCEPCION, JOSE A · 2018 to 2022
$1.8MMidbrain Neural Circuit Elements That Underlie Cue-Reward AssociationsR01DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2012 to 2016
$1.6MOptopharmacology and Sensors for Dissecting Opioid Action In VivoR61DA051489 · NIDA · UNIVERSITY OF WASHINGTON · PI BRUCHAS, MICHAEL R., GU, LIANGCAI · 2020 to 2022
$1.2MOptopharmacology and Sensors for Dissecting Opioid Action In VivoR33DA051489 · NIDA · UNIVERSITY OF WASHINGTON · PI BRUCHAS, MICHAEL R., GU, LIANGCAI · 2023 to 2024
$1.0MNIDA NIH HHS F31 DA051124NIDA NIH HHS F32 DA043999NIDA NIH HHS K99 DA049862NIDA NIH HHS P30 DA048736NIDA NIH HHS R00 DA049862NIDA NIH HHS R01 DA032750NIDA NIH HHS R01 DA033396NIDA NIH HHS R01 DA038168NIDA NIH HHS R01 DA041781NIDA NIH HHS R01 DA042499NIDA NIH HHS R01 DA045463NIDA NIH HHS R33 DA051489NIDA NIH HHS R37 DA032750NIDA NIH HHS R37 DA033396NIDA NIH HHS R61 DA051489NIDDK NIH HHS K99 DK121883NIDDK NIH HHS R00 DK121883NINDS NIH HHS T32 NS007205
Abstract
µ-Opioid peptide receptor (MOPR) stimulation alters respiration, analgesia and reward behaviour, and can induce substance abuse and overdose
Indexed as
RewardAnalgesics, OpioidAnimalsEnkephalinsFemaleMaleMiceMice, KnockoutNucleus AccumbensReceptors, Opioid, muAnalgesics, OpioidEnkephalinsReceptors, Opioid, mu
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.