Evidence map›Paper›PMID 34646014›Full record

ArticleNature2021

The cellular environment shapes the nuclear pore complex architecture.

Anthony P Schuller, Matthias Wojtynek, David Mankus, Meltem Tatli, Rafael Kronenberg-Tenga, Saroj G Regmi, Phat V Dip, Abigail K R Lytton-Jean, Edward J Brignole, Mary Dasso and 3 more

Abstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed.

  1. Review
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  9. Review
  10. HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
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  18. Article
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  20. Review

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Anthony P Schuller *Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Matthias Wojtynek *Department of Biochemistry, University of Zurich, Zurich, Switzerland.
David MankusKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9979-7608
Meltem TatliDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.
Rafael Kronenberg-TengaDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.
Saroj G RegmiDivision of Molecular and Cellular Biology, National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Phat V DipDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Abigail K R Lytton-JeanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Edward J BrignoleDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Mary DassoDivision of Molecular and Cellular Biology, National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5410-1371
Karsten WeisDepartment of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-7224-925X
Ohad MedaliaDepartment of Biochemistry, University of Zurich, Zurich, Switzerland. omedalia@bioc.uzh.ch.ORCID http://orcid.org/0000-0003-0994-2937
Thomas U SchwartzDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. tus@mit.edu.ORCID http://orcid.org/0000-0001-8012-1512

Funding

High Resolution Assembly Structure of The Nuclear Pore ComplexR01GM077537 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SCHWARTZ, THOMAS · 2007 to 2019
$4.3M
Structure-Function of Nucleo-Cytoplasmic CommunicationR35GM141834 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SCHWARTZ, THOMAS · 2021 to 2025
$2.0M
NIGMS NIH HHS R01 GM077537NIGMS NIH HHS R35 GM141834
6 · The paper itself

Abstract

Nuclear pore complexes (NPCs) create large conduits for cargo transport between the nucleus and cytoplasm across the nuclear envelope (NE)

Indexed as

Models, StructuralCell Line, TumorCell NucleusCytoplasmElectron Microscope TomographyHumansNuclear PoreNuclear Pore Complex Proteinsnuclear pore complex protein 96Nuclear Pore Complex Proteins

Identifiers

PMID34646014
PMCPMC8550940

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.