ArticleNature2021
Oestrogen engages brain MC4R signalling to drive physical activity in female mice.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed, 125 citations in OpenAlex.
- Cellular mechanism of gain-of-function mutation I173M in sheep MC4R gene identified in year-round and seasonal estrus breeds through whole-genome resequencing.Genetics, selection, evolution : GSE · 2026Article
- Ablation of microglial estrogen receptor alpha predisposes male mice to diet-induced obesity.Metabolism: clinical and experimental · 2026Article
- Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model.eLife · 2026Article
- Hypothalamic actions of estrogens in the regulation of energy and glucose homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Sexual dimorphism in the development and function of the melanocortin system.Reviews in endocrine & metabolic disorders · 2026Review
- Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026Review
- The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026Review
- TOX3 in hypothalamic POMC-lineage cells regulates energy balance via the PTEN-AKT signaling axis.Nature communications · 2026Article
- Regulation of physical activity and energy expenditure through Phf6 in the medial preoptic area.Nature communications · 2026Article
- Congenital vs adult-onset estrogen deficiency in female mice: physiological effects and implications for therapy.The Journal of endocrinology · 2026Article
- Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus.Cell reports · 2026Article
- Identification of a neural basis for anorexia nervosa.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in the impact of sedentary time on early-onset metabolic multimorbidity: evidence from a study of over 20,000 young adults.Biology of sex differences · 2026Article
- Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model.bioRxiv : the preprint server for biology · 2026Article
- Sex-Specific Thermoregulatory Effects of Estrogen Signaling in Reprimo Lineage Cells.Endocrinology · 2025Article
- Large Peritoneal Macrophages Promote the Resolution of Inflammation in Injured Endometrium.Inflammation · 2025Article
- Sex-specific thermoregulatory effects of estrogen signaling inbioRxiv : the preprint server for biology · 2025Article
- Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake.The FEBS journal · 2025Article
- POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons.eLife · 2025Article
- Neuroendocrinology and the Genetics of Obesity.Endocrinology · 2025Review
17 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 3 institutions in 1 country.
William C KrauseDepartment of Cellular and Molecular Pharmacology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Ruben RodriguezDepartment of Cellular and Molecular Pharmacology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8174-2556
Bruno GegenhuberSchool of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Navneet MatharuDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
Andreas N RodriguezDepartment of Cellular and Molecular Pharmacology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Adriana M Padilla-RogerGraduate Program in Neuroscience, University of California San Francisco, San Francisco, USA.ORCID http://orcid.org/0000-0003-4858-8221
Kenichi TomaDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Candice B HerberDepartment of Cellular and Molecular Pharmacology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Stephanie M CorreaDepartment of Cellular and Molecular Pharmacology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6221-689X
Xin DuanDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5260-8972
Nadav AhituvDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7434-8144
Jessica TollkuhnCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. tollkuhn@cshl.edu.ORCID http://orcid.org/0000-0001-5991-7620
Holly A IngrahamDepartment of Cellular and Molecular Pharmacology, School of Medicine, University of California San Francisco, San Francisco, CA, USA. holly.ingraham@ucsf.edu.ORCID http://orcid.org/0000-0001-6739-2967
University of California, San Francisco · USCold Spring Harbor Laboratory · USUniversity of California, Los Angeles · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4MUCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALKA M. KANAYA · 2015 to 2026
$14.6MEpigenetic Regulation of Sex Differences in the BrainR01MH113628 · NIMH · COLD SPRING HARBOR LABORATORY · PI Jessica Tollkuhn · 2018 to 2026
$4.8MCSHL Watson School of Biological SciencesT32GM065094 · NIGMS · COLD SPRING HARBOR LABORATORY · PI GANN, ALEXANDER · 2002 to 2021
$4.8MPredoctoral Training in NeurobiologyT32NS115706 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMUEL JEREMY PLEASURE · 2020 to 2026
$3.4MMassively parallel dissection of psychiatric regulatory networksR01MH109907 · NIMH · J. DAVID GLADSTONE INSTITUTES · PI AHITUV, NADAV, POLLARD, KATHERINE S. · 2016 to 2020
$3.4MMechanisms Underlying Type II Cadherin Guided Assembly of Retinal CircuitsR01EY030138 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Xin Duan · 2020 to 2026
$3.2MDissecting a hormone-responsive processor for female activity and repetitive behaviorR01DK121657 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A. · 2020 to 2024
$2.9MArcuate ERa Signaling in Central Control of Female Bone MetabolismR01AG062331 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A. · 2019 to 2023
$2.3MIntegrative interpretation of the organismal consequences of non-coding variationR01CA197139 · NCI · UNIVERSITY OF WASHINGTON · PI COOPER, GREGORY MICHAEL, SHENDURE, JAY ASHOK · 2015 to 2017
$1.9MA female-specific neuroendocrine center controlling energy expenditureK01DK098320 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CORREA, STEPHANIE · 2013 to 2015
$370kAmerican Heart Association-American Stroke AssociationNCATS NIH HHS UL1 TR001881NCI NIH HHS R01 CA197139NEI NIH HHS R01 EY030138NIA NIH HHS R01 AG062331NIDDK NIH HHS K01 DK098320NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK121657NIGMS NIH HHS K12 GM081266NIGMS NIH HHS T32 GM065094NIH HHS 2T32 GM065094NIMH NIH HHS F31 MH124365NIMH NIH HHS R01 MH109907NIMH NIH HHS R01 MH113628NINDS NIH HHS T32 NS115706
Abstract
Oestrogen depletion in rodents and humans leads to inactivity, fat accumulation and diabetes
Indexed as
Signal TransductionAnimalsBrainCRISPR-Cas SystemsEnergy MetabolismEstrogen Receptor alphaEstrogensFemaleGene EditingHippocampusMaleMelanocortinsMiceNeuronsObesityPhysical ExertionEstrogen Receptor alphaEstrogensMC4R protein, mouseMelanocortinsReceptor, Melanocortin, Type 4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.