Evidence map›Paper›PMID 34645895›Full record

Trial reportScientific reports2021

Interindividual variability of electric fields during transcranial temporal interference stimulation (tTIS).

Jill von Conta, Florian H Kasten, Branislava Ćurčić-Blake, André Aleman, Axel Thielscher, Christoph S Herrmann

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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  2. Transcranial Temporal Interference Stimulation of the Right Globus Pallidus in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jill von ContaExperimental Psychology Lab, Department of Psychology, European Medical School, Cluster of Excellence "Hearing4All", Carl Von Ossietzky University, Ammerländer Heerstr. 114-118, 26129, Oldenburg, Germany.
Florian H KastenExperimental Psychology Lab, Department of Psychology, European Medical School, Cluster of Excellence "Hearing4All", Carl Von Ossietzky University, Ammerländer Heerstr. 114-118, 26129, Oldenburg, Germany.
Branislava Ćurčić-BlakeDepartment of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
André AlemanDepartment of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Axel ThielscherDanish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark.
Christoph S HerrmannExperimental Psychology Lab, Department of Psychology, European Medical School, Cluster of Excellence "Hearing4All", Carl Von Ossietzky University, Ammerländer Heerstr. 114-118, 26129, Oldenburg, Germany. christoph.herrmann@uni-oldenburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial temporal interference stimulation (tTIS) is a novel non-invasive brain stimulation technique for electrical stimulation of neurons at depth. Deep brain regions are generally small in size, making precise targeting a necessity. The variability of electric fields across individual subjects resulting from the same tTIS montages is unknown so far and may be of major concern for precise tTIS targeting. Therefore, the aim of the current study is to investigate the variability of the electric fields due to tTIS across 25 subjects. To this end, the electric fields of different electrode montages consisting of two electrode pairs with different center frequencies were simulated in order to target selected regions-of-interest (ROIs) with tTIS. Moreover, we set out to compare the electric fields of tTIS with the electric fields of conventional tACS. The latter were also based on two electrode pairs, which, however, were driven in phase at a common frequency. Our results showed that the electric field strengths inside the ROIs (left hippocampus, left motor area and thalamus) during tTIS are variable on single subject level. In addition, tTIS stimulates more focally as compared to tACS with much weaker co-stimulation of cortical areas close to the stimulation electrodes. Electric fields inside the ROI were, however, comparable for both methods. Overall, our results emphasize the potential benefits of tTIS for the stimulation of deep targets, over conventional tACS. However, they also indicate a need for individualized stimulation montages to leverage the method to its fullest potential.

Indexed as

Models, NeurologicalTranscranial Direct Current StimulationAdultFemaleHumansMaleMotor CortexThalamus

Identifiers

PMID34645895
PMCPMC8514596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.