Evidence map›Paper›PMID 34645893›Full record

ArticleScientific reports2021

Machine learning identification of specific changes in myeloid cell phenotype during bloodstream infections.

Christian Gosset, Jacques Foguenne, Mickaël Simul, Olivier Tomsin, Hayet Ammar, Nathalie Layios, Paul B Massion, Pierre Damas, André Gothot

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Christian GossetUniversity of Liège, Liège, Belgium. c.gosset@uliege.be.
Jacques FoguenneDepartment of Hematobiology and Immuno-Hematology, Liège University Hospital, Liège, Belgium.
Mickaël SimulDepartment of Hematobiology and Immuno-Hematology, Liège University Hospital, Liège, Belgium.
Olivier TomsinDepartment of Hematobiology and Immuno-Hematology, Liège University Hospital, Liège, Belgium.
Hayet AmmarIntensive Care Unit, Liège University Hospital, Liège, Belgium.
Nathalie LayiosIntensive Care Unit, Liège University Hospital, Liège, Belgium.
Paul B MassionIntensive Care Unit, Liège University Hospital, Liège, Belgium.
Pierre DamasUniversity of Liège, Liège, Belgium.
André GothotUniversity of Liège, Liège, Belgium.
University of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early identification of bacteremia is critical for ensuring appropriate treatment of nosocomial infections in intensive care unit (ICU) patients. The aim of this study was to use flow cytometric data of myeloid cells as a biomarker of bloodstream infection (BSI). An eight-color antibody panel was used to identify seven monocyte and two dendritic cell subsets. In the learning cohort, immunophenotyping was applied to (1) control subjects, (2) postoperative heart surgery patients, as a model of noninfectious inflammatory responses, and (3) blood culture-positive patients. Of the complex changes in the myeloid cell phenotype, a decrease in myeloid and plasmacytoid dendritic cell numbers, increase in CD14

Indexed as

AdultAgedAlgorithmsArea Under CurveBacteremiaBiomarkersCritical CareDendritic CellsFemaleFlow CytometryGPI-Linked ProteinsGranulocytesHumansImmunophenotypingInflammationIntensive Care UnitsBiomarkersCD14 protein, humanFCGR3B protein, humanGPI-Linked ProteinsIL3RA protein, humanInterleukin-3 Receptor alpha SubunitLipopolysaccharide ReceptorsReceptors, IgG

Identifiers

PMID34645893
PMCPMC8514545
OpenAlexW3206016362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.