ArticleTranslational psychiatry2021
Association between circadian activity rhythms and mood episode relapse in bipolar disorder: a 12-month prospective cohort study.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Digital Markers for Passive Remote Monitoring of Bipolar Disorder: Systematic Review.JMIR mental health · 2026Pooled it
- Allostatic and Circadian Drives in Patients with Bipolar Disorder in Depressive Episodes or with Post-Traumatic Stress Disorder Versus Healthy Controls: Neuroendocrine Comparison Through Cortisol and 6-Sulfatoxymelatonin Overnight Urine Excretion.International journal of molecular sciences · 2026Article
- Essential Information About Chronobiology and Chronotherapy for the Optimal Care of People With Bipolar Disorders: An Expert Consensus.Bipolar disorders · 2026Article
- Daily Rhythms in Clock Gene mRNA Expression in Serotonergic Brain Regions of Adult Male Rats.Journal of biological rhythms · 2026Article
- The Theory of Metabolic Jet Lag in Bipolar Disorder: A Pilot Feasibility Study Exploring the Association Between Eating Rhythm Disruption and Illness Burden Parameters.Bipolar disorders · 2026Article
- Sedentary Behavior and Physical Activity in Individuals With Bipolar Disorder: An Evidence Synthesis and Position Statement From the ISBD Nutrition and Exercise Task Force (NExT).Bipolar disorders · 2026Review
- Postpartum Psychosis: could genetic vulnerability to insomnia or short sleep duration be protective?Translational psychiatry · 2026Article
- Lithium and valproic acid in bipolar disorder: Beyond mood stabilization, the overlooked role of sleep.World journal of psychiatry · 2025Article
- Light therapy for bipolar disorders: Clinical recommendations from the international society for bipolar disorders (ISBD) Chronobiology and Chronotherapy Task Force.Dialogues in clinical neuroscience · 2025Review
- Self-assessment and rest-activity rhythm monitoring for effective bipolar disorder management: a longitudinal actigraphy study.International journal of bipolar disorders · 2025Article
- The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Moving toward precision and personalized treatment strategies in psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Forecasting the course of bipolar disorder using rest-activity rhythms: Protocol for a multi-study modelling project.Wellcome open research · 2025Article
- The integrative role of melatonin in psychiatric disorders: A systematic review of evidence from circadian biology, lifestyle medicine, and psychoneuroimmunology.BioMedicine · 2025Review
- NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice.Nature communications · 2024Article
- Longitudinal Assessment of Seasonal Impacts and Depression Associations on Circadian Rhythm Using Multimodal Wearable Sensing: Retrospective Analysis.Journal of medical Internet research · 2024Article
- Bipolar Disorder, Circadian Rhythm and Clock Genes.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Review
- Investigating Rhythmicity in App Usage to Predict Depressive Symptoms: Protocol for Personalized Framework Development and Validation Through a Countrywide Study.JMIR research protocols · 2024Article
- Patient-reported outcomes on sleep quality and circadian rhythm during treatment with intravenous ketamine for treatment-resistant depression.Therapeutic advances in psychopharmacology · 2024Article
- Sleep and Postpartum Psychosis: A Narrative Review of the Existing Literature.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A significant proportion of patients with bipolar disorder experience mood episode relapses. We examined whether circadian activity rhythms were associated with mood episode relapses in patients with bipolar disorder. This prospective cohort study included outpatients with bipolar disorder who participated in a study titled "Association between the Pathology of Bipolar Disorder and Light Exposure in Daily Life (APPLE) cohort study." The participants' physical activity was objectively assessed using a wrist-worn accelerometer over 7 consecutive days for the baseline assessment and then at the 12-month follow-up for mood episode relapses. The levels and timing of the circadian activity rhythms were estimated using a cosinor analysis and a nonparametric circadian rhythm analysis. Of the 189 participants, 88 (46%) experienced mood episodes during follow-up. The Cox proportional hazards model adjusting for potential confounders showed that a robust circadian activity rhythm, including midline-estimating statistic of rhythm (MESOR) and amplitude by cosinor analysis and 10 consecutive hours with the highest amplitude values (M10) by the nonparametric circadian rhythm analysis, was significantly associated with a decrease in mood episode relapses (per counts/min, hazard ratio [95% confidence interval]: MESOR, 0.993 [0.988-0.997]; amplitude, 0.994 [0.988-0.999]; and M10, 0.996 [0.993-0.999]). A later timing of the circadian activity rhythm (M10 onset time) was significantly associated with an increase in the depressive episode relapses (per hour; 1.109 [1.001-1.215]). We observed significant associations between circadian activity rhythms and mood episode relapses in bipolar disorder.
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