Evidence map›Paper›PMID 34645753›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Slowly Progressive Male Alport Syndrome Evaluated by Serial Biopsy: Importance of Type IV Collagen Staining.

Masayo Sato, Shun Manabe, Mitsuyo Itabashi, Shigeru Horita, Orie Hirose, Moe Kawashima, Miki Nishida, Hiroshi Kataoka, Sekiko Taneda, Toshio Mochizuki and 1 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Masayo SatoDepartment of Nephrology, Tokyo Women's Medical University, Japan.
Shun ManabeDepartment of Nephrology, Tokyo Women's Medical University, Japan.
Mitsuyo ItabashiDepartment of Nephrology, Tokyo Women's Medical University, Japan.
Shigeru HoritaDepartment of Clinical Laboratory Medicine, Tokyo Women's Medical University Hospital, Japan.
Orie HiroseDepartment of Pathology, Tokyo Women's Medical University, Japan.
Moe KawashimaDepartment of Nephrology, Tokyo Women's Medical University, Japan.
Miki NishidaDepartment of Nephrology, Tokyo Women's Medical University, Japan.
Hiroshi KataokaDepartment of Nephrology, Tokyo Women's Medical University, Japan.
Sekiko TanedaDepartment of Pathology, Tokyo Women's Medical University, Japan.
Toshio MochizukiDepartment of Nephrology, Tokyo Women's Medical University, Japan.
Kosaku NittaDepartment of Nephrology, Tokyo Women's Medical University, Japan.
Tokyo Women's Medical University · JPTokyo Women's Medical University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A slowly progressive middle-aged man initially diagnosed with thin basement membrane nephropathy based on extensive thinning of the glomerular basement membrane (GBM) was subsequently diagnosed with Alport syndrome (AS) by a serial renal biopsy eight years later. The ultrastructural analysis of the second biopsy indicated thickening and wrinkling with mild reticulation in the GBM, consistent with AS. However, a retrospective analysis of the first biopsy revealed mild attenuation of type IV collagen α5 chain staining, suggesting a potential diagnosis of AS, despite the lack of ultrastructural features of AS. We herein report the clinical usefulness of type IV collagen staining in the early diagnosis of AS.

Indexed as

Collagen Type IVNephritis, HereditaryBasement MembraneBiopsyFemaleHumansMaleMiddle AgedRetrospective StudiesStaining and LabelingCollagen Type IVAlport syndromerenal biopsythin basement membrane nephropathytype IV collagen

Identifiers

PMID34645753
PMCPMC9107991
OpenAlexW3207404963

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.