ArticleProceedings of the National Academy of Sciences of the United States of America2021
The human olfactory bulb processes odor valence representation and cues motor avoidance behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Separable and integrated pleasantness coding for appetitive and aversive odors across olfactory and ventral prefrontal cortices.Nature communications · 2026Article
- Olfactory bulb-cortex oscillations encode perceived odor intensity rather than concentration.PLoS biology · 2026Article
- Gamma and beta oscillatory signatures of the human olfactory bulb encode odor valence and sampling.iScience · 2026Article
- High-Accuracy Detection of Odor Presence from Olfactory Bulb Local Field Potentials via Deep Neural Networks.Sensors (Basel, Switzerland) · 2026Article
- Effects of Olfactory Valence on the Neural and Behavioral Dynamics of Approach-Avoidance: An EEG Study.Brain sciences · 2025Article
- Tastes and retronasal odours evoke a shared flavour-specific neural code in the human insula.Nature communications · 2025Article
- Non-contact radiofrequency stimulation to the olfactory nerve of human subjects.APL bioengineering · 2025Article
- Motor Cortex Disinhibition Correlates with Olfactory Dysfunction in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Exploring the feasibility of olfactory brain-computer interfaces.Scientific reports · 2025Article
- The effect of social settings and olfactory environments on spontaneous movement synchrony.Scientific reports · 2025Article
- Long-lasting effects of lavender exposure on brain resting-state networks in healthy women.Frontiers in neuroscience · 2025Article
- The human olfactory bulb communicates perceived odor valence to the piriform cortex in the gamma band and receives a refined representation back in the beta band.PLoS biology · 2024Article
- Value-related learning in the olfactory bulb occurs through pathway-dependent perisomatic inhibition of mitral cells.PLoS biology · 2024Article
- What Does the Human Olfactory System Do, and How Does It Do It?Annual review of psychology · 2024Review
- Olfactory neurofeedback: current state and possibilities for further development.Frontiers in human neuroscience · 2024Article
- Representational maps in the brain: concepts, approaches, and applications.Frontiers in cellular neuroscience · 2024Review
- When are puppies receptive to emotion-induced human chemosignals? The cases of fear and happiness.Animal cognition · 2023Observational
- An olfactory-based Brain-Computer Interface: electroencephalography changes during odor perception and discrimination.Frontiers in behavioral neuroscience · 2023Article
- Spatiotemporal dynamics of odor representations in the human brain revealed by EEG decoding.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Perceptual odor qualities predict successful odor identification in old age.Chemical senses · 2022Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Determining the valence of an odor to guide rapid approach-avoidance behavior is thought to be one of the core tasks of the olfactory system, and yet little is known of the initial neural mechanisms supporting this process or of its subsequent behavioral manifestation in humans. In two experiments, we measured the functional processing of odor valence perception in the human olfactory bulb (OB)-the first processing stage of the olfactory system-using a noninvasive method as well as assessed the subsequent motor avoidance response. We demonstrate that odor valence perception is associated with both gamma and beta activity in the human OB. Moreover, we show that negative, but not positive, odors initiate an early beta response in the OB, a response that is linked to a preparatory neural motor response in the motor cortex. Finally, in a separate experiment, we show that negative odors trigger a full-body motor avoidance response, manifested as a rapid leaning away from the odor, within the time period predicted by the OB results. Taken together, these results demonstrate that the human OB processes odor valence in a sequential manner in both the gamma and beta frequency bands and suggest that rapid processing of unpleasant odors in the OB might underlie rapid approach-avoidance decisions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.