Evidence map›Paper›PMID 34645669›Full record

ReviewJournal for immunotherapy of cancer2021

Immunological configuration of ovarian carcinoma: features and impact on disease outcome.

Jitka Fucikova, An Coosemans, Sandra Orsulic, David Cibula, Ignace Vergote, Lorenzo Galluzzi, Radek Spisek

Open access · goldAbstract readReview
In one paragraph

Review in Journal for immunotherapy of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  17. Review
  18. Mesenchymal ovarian cancer cells promote CD8NPJ systems biology and applications · 2023
    Article
  19. Heterogeneity and treatment landscape of ovarian carcinoma.Nature reviews. Clinical oncology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 5 countries.

Jitka FucikovaSotio Biotech, Prague, Czech Republic fucikova@sotio.com.ORCID 0000-0002-8423-479X
An CoosemansDepartment of Oncology, Laboratory of Tumor Immunology and Immunotherapy, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.ORCID 0000-0002-7321-4339
Sandra OrsulicUCLA David Geffen School of Medicine and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.
David CibulaGynecologic Oncology Center, Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.ORCID 0000-0001-6387-9356
Ignace VergoteDivision of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospital Leuven, Leuven, Belgium.
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Radek SpisekSotio Biotech, Prague, Czech Republic.
Charles University · CZCancer Institute (WIA) · INCornell University · USGynecologic Oncology Group · USKU Leuven · BEUniversity of California, Los Angeles · US

Funding

Cancer-Associated Fibroblasts Alter the Composition of B Cells I Solid Malignancies - Diversity SupplementR01CA208753 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ORSULIC, SANDRA · 2016 to 2020
$2.2M
Precancer Niche Formation in the Fallopian TubeI01BX004974 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI ORSULIC, SANDRA · 2020 to 2024
–
BLRD VA I01 BX004974NCI NIH HHS R01 CA208753
6 · The paper itself

Abstract

Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive to immune checkpoint inhibitors, correlating with a tumor microenvironment that exhibits poor infiltration by immune cells and active immunosuppression. Here, we comparatively summarize the humoral and cellular features of primary and metastatic EOC, comparatively analyze their impact on disease outcome, and propose measures to alter them in support of treatment sensitivity and superior patient survival.

Indexed as

Carcinoma, Ovarian EpithelialFemaleHumansImmunosuppression TherapyImmunotherapyTreatment OutcomeTumor Microenvironmentfemalegenital neoplasmsimmunologic surveillanceimmunotherapytumor biomarkerstumor microenvironment

Identifiers

PMID34645669
PMCPMC8515436
OpenAlexW3206174949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.