Evidence map›Paper›PMID 34645615›Full record

ArticleBMJ open diabetes research & care2021

Plasma protein

Elham Memarian, Leen M 't Hart, Roderick C Slieker, Roosmarijn F L Lemmers, Amber A van der Heijden, Femke Rutters, Giel Nijpels, Emma Schoep, Aloysius G Lieverse, Eric J G Sijbrands and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open diabetes research & care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Post‑translational modifications in diabetic kidney disease (Review).International journal of molecular medicine · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Glycosylation in kidney diseases.Precision clinical medicine · 2025
    Review
  8. Article
  9. Review
  10. Dynamic glycosylation remodeling in neurological disorders.Frontiers in molecular neuroscience · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. The Human BloodJACS Au · 2024
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Elham Memarian *Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Leen M 't Hart *Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-4401-2938
Roderick C SliekerDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-0961-9152
Roosmarijn F L LemmersDepartment of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands.
Amber A van der HeijdenAmsterdam UMC, Vrije Universiteit Amsterdam, Department of General Practice Medicine, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Femke RuttersAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Giel NijpelsAmsterdam UMC, Vrije Universiteit Amsterdam, Department of General Practice Medicine, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Emma SchoepDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Aloysius G LieverseDepartment of Internal Medicine, Maxima Medical Center, Eindhoven, The Netherlands.
Eric J G SijbrandsDepartment of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands.
Manfred WuhrerCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Mandy van Hoek *Department of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands m.vanhoek@erasmusmc.nl.ORCID 0000-0002-2957-5436
Viktoria Dotz *Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-9888-7409
Leiden University Medical Center · NLAmsterdam University Medical Centers · NLErasmus MC · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough associations of total plasma RESEARCH DESIGN AND

methodsBlood plasma samples and technical replicates were pipetted into 96-well plates in a randomized manner. Peptide:N-glycosidase F (PNGase F) was used to release

resultsOur results demonstrated similarities between incident and prevalent complications. The strongest association for prevalent cardiovascular disease was a high level of bisection on a group of diantennary glycans (A2FS0B; OR=1.38, p=1.34×10

conclusionsThese findings may provide a glance on how TPNG patterns change before complications emerge, paving the way for future studies on prediction biomarkers and potentially disease mechanisms.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2Retinal DiseasesBlood ProteinsGlycosylationHumansPlasmaBlood Proteinsbiomarkersdiabetes complicationsglycosylation

Identifiers

PMID34645615
PMCPMC8515459
OpenAlexW3205600483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.