Evidence map›Paper›PMID 34645538›Full record

ArticleEpidemiology and psychiatric sciences2021

Risk of COVID-19 diagnosis and death in patients with mental illness: a cohort study.

Jeon-Yeon Seon, Sunjea Kim, Minha Hong, Min Kyoung Lim, In-Hwan Oh

Abstract read
In one paragraph

Article in Epidemiology and psychiatric sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeon-Yeon SeonHealth Insurance Research Institute, National Health Insurance Service, Wonju-si, Republic of Korea.ORCID https://orcid.org/0000-0002-0080-168X
Sunjea KimHealth Insurance Research Institute, National Health Insurance Service, Wonju-si, Republic of Korea.ORCID https://orcid.org/0000-0002-2461-0175
Minha HongDepartment of Psychiatry, Myongji Hospital, Hanyang University, College of Medicine, Goyang-si, Republic of Korea.ORCID https://orcid.org/0000-0003-4924-1107
Min Kyoung LimHealth Insurance Research Institute, National Health Insurance Service, Wonju-si, Republic of Korea.ORCID https://orcid.org/0000-0002-4465-9793
In-Hwan OhDepartment of Preventive Medicine, Kyung Hee University School of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-3388-8961

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPatients with mental illness are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection because of behavioural changes associated with cognitive deterioration, especially without their caregivers. While studies have reported that SARS-CoV-2 infection risk and severe clinical outcomes are high among patients with mental illness, there is a lack of quantitative research supporting this claim. This study investigates if SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19)-related death are higher in patients with mental illness than among those without a mental disorder.

methodsA cohort study was conducted using the COVID-19 database of the National Health Insurance Service in South Korea. A total of 123 480 patients aged ⩾20 years who visited a hospital between 1 January 2020 and 30 May 2020 were analysed. Mental disorder diagnoses and types were determined based on 2019 medical records, and a multivariate logistic regression model was used to calculate the odds ratios (ORs) for SARS-CoV-2 infection and deaths.

resultsThe ORs for SARS-CoV-2 infection (OR 1.58; 95% CI 1.45-1.71) and COVID-19-related death (OR 2.18; 95% CI 1.57-3.04) were high among patients with mental illness. The OR of SARS-CoV-2 infection was higher among patients with severe mental illness (OR 2.60; 95% CI 2.21-3.06), dementia (OR 1.90; 95% CI 1.62-2.22) and substance use disorder (OR 4.98, 95% CI 3.60-6.88). The OR for COVID-19-related death was high among patients with severe mental illness (OR 3.53; 95% CI 1.82-6.83) and dementia (OR 2.12; 95% CI 1.39-3.22).

conclusionsPatients with mental illness are at high risk for SARS-CoV-2 infection and COVID-19-related death. Behavioural changes associated with cognitive deterioration and long-term care facility residence increase SARS-CoV-2 infection risk, and severe medical conditions and delayed treatment increase the COVID-19-related mortality risk in patients with mental illness. Patients with mental illness are a priority target population for COVID-19 prevention and treatment, and it is important to plan prevention measures that address their needs.

Indexed as

COVID-19Mental DisordersAgedCohort StudiesCOVID-19 TestingHumansSARS-CoV-2Bipolar disorderchronic conditionsdementiaschizophrenia

Identifiers

PMID34645538
PMCPMC8564032

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.