Evidence map›Paper›PMID 34645450›Full record

ArticleJournal of nanobiotechnology2021

Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma.

Yunguang Zhang, Si Sun, Haile Liu, Qinjuan Ren, Wenting Hao, Qi Xin, Jiangang Xu, Hao Wang, Xiao-Dong Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. AuACS nano · 2026
    Article
  3. Clusterzymes-driven therapy: ultrasmall CuJournal of nanobiotechnology · 2026
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yunguang Zhang *School of Science, Xi'an University of Posts and Telecommunications, Xi'an, 710121, China.
Si Sun *Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin, 300350, China.
Haile LiuTianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin, 300350, China.
Qinjuan RenTianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin, 300350, China.
Wenting HaoTianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.
Qi XinTianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.
Jiangang XuSchool of Science, Xi'an University of Posts and Telecommunications, Xi'an, 710121, China. xjgo@xupt.edu.cn.
Hao WangTianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China. hao_wang@tju.edu.cn.
Xiao-Dong ZhangTianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin, 300350, China. xiaodongzhang@tju.edu.cn.
Tianjin University · CNXi’an University of Posts and Telecommunications · CN

Funding

cas interdisciplinary innovation team JCTD-2020-08national natural science foundation of china 81471786national natural science foundation of china 81971744national natural science foundation of china 91859101national natural science foundation of china U1932107natural science foundation of tianjin city 19JCZDJC34000the foundation of 'peiyang young researcher' program of tianjin university the foundation of 'peiyang young researcher' program of tianjin university
6 · The paper itself

Abstract

backgroundNeurotrauma is a worldwide public health problem which can be divided into primary and secondary damge. The primary damge is caused by external forces and triggers the overproduction of peroxides and superoxides, leading to long-lasting secondary damage including oxidative stress, wound infection and immunological reactions. The emerging catalysts have shown great potential in the treatment of brain injury and neurogenic inflammation, but are limited to biosafety issues and delivery efficiency.

resultsHerein, we proposed the noninvasive delivery route to brain trauma by employing highly active gold clusters with enzyme-like activity to achieve the early intervention. The decomposition rate to H

conclusionsPresent work shows noninvasive treatment is a promising route for early intervention of brain trauma.

Indexed as

AntioxidantsGoldMetal NanoparticlesAnimalsBrainBrain Injuries, TraumaticCatalysisDisease Models, AnimalHydrogen PeroxideMaleMiceMice, Inbred C57BLMorris Water Maze TestOxidative StressAntioxidantsGoldHydrogen PeroxideCatalytic activityGold clustersNoninvasive administrationTraumatic brain injury

Identifiers

PMID34645450
PMCPMC8513369
OpenAlexW3176035025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.