Evidence map›Paper›PMID 34645414›Full record

ArticleBMC infectious diseases2021

Intestinal microbiota has important effect on severity of hand foot and mouth disease in children.

Chenguang Shen, Yi Xu, Jingkai Ji, Jinli Wei, Yujin Jiang, Yang Yang, Minghui Yang, Huaxin Huang, Rongrong Zou, Chunxiao Fang and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. T-Cell Receptor Sequences Identify Combined Coxsackievirus-International journal of molecular sciences · 2024
    Article
  3. Article
  4. Impact of the Microbiota on Viral Infections.Annual review of virology · 2023
    Review
  5. Hand, Foot, and Mouth Disease: A Narrative Review.Recent advances in inflammation & allergy drug discovery · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 2 countries.

Chenguang Shen *Graduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China. 5942342qq@163.com.
Yi Xu *Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China.
Jingkai Ji *BGI-Shenzhen, Shenzhen, 518083, China.
Jinli Wei *Graduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Yujin Jiang *Graduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Yang YangGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Minghui YangGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Huaxin HuangGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Rongrong ZouGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Chunxiao FangGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China.
Fansen ZengGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China.
Fengxia YangGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China.
Xinfa WangGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Jing YuanGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Jianmin LiGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Xianfeng WangGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Huanming YangBGI-Shenzhen, Shenzhen, 518083, China.
Sitang GongGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China.
Hui WangGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.
Huimin XiaGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China. sitangg@126.com.
Jinmin MaBGI-Shenzhen, Shenzhen, 518083, China. majinmin@genomics.cn.
Yingxia LiuGraduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China. 34762354@qq.com.
University of South China · CNGuangzhou Medical University · CNBGI Group (China) · CNChina National GeneBank · CNUniversity of Oxford · GB

Funding

Guangdong Basic and Applied Basic Research Foundation 2020A1515010368National Science and Technology Major Project of China 2017ZX10303406Science, Technology and Innovation Commission of Shenzhen Municipality JCYJ20170817145915789Shenzhen Science and Technology Innovation Commission for Research and Development Project JCYJ20190809183205622
6 · The paper itself

Abstract

backgroundThe incidence of hand foot and mouth disease (HFMD) has increased in recent years, making it a very common childhood illness worldwide. The relationship between different enterovirus genotypes and disease severity is not clearly understood. Given that enteroviruses are transmitted through the gastrointestinal tract, we hypothesized that variation in intestinal microorganisms of the host might play a role in the prognosis of HFMD.

methodsWe carried out a meta-transcriptomic-wide association study of fecal samples obtained from a cohort of children (254 patients, 227 tested positive for enterovirus, including 16 patients co-infectied with 2 kinds of enterovirus) with mild and severe HFMD and healthy controls.

resultsWe found there was no significant difference in the amount of each virus type between the mild and severe cases. Genes of enterovirus 71 (EV71) and coxsackievirus A (CV-A) from the severe and mild cases did not show significant clustering. Clostridium sp. L2-50 and Bacteroides stercoris ATCC 43183 were enriched in the guts of children with severe HFMD and KEGG enrichment was found between mild and severe cases.

conclusionsIntestinal microorganisms appear to interact with enterovirus to determine the progression of HFMD. Genes of Bacteroides and Clostridium may be used as predictive markers for a more efficient prognosis and intervention. The enrichment of intestinal bacteria genes with functions may facilitate the development of severe symptoms for HFMD patients.

Indexed as

EnterovirusEnterovirus A, HumanGastrointestinal MicrobiomeHand, Foot and Mouth DiseaseBacteroidesChildChinaHumansInfantBacteroides and ClostridiumHand foot and mouth diseaseIntestinal microorganismsPredictive markers

Identifiers

PMID34645414
PMCPMC8513321
OpenAlexW3139438849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.