Evidence map›Paper›PMID 34644593›Full record

ReviewNeuroImage2021

Contribution of animal models toward understanding resting state functional connectivity.

Patricia Pais-Roldán, Celine Mateo, Wen-Ju Pan, Ben Acland, David Kleinfeld, Lawrence H Snyder, Xin Yu, Shella Keilholz

Open access · goldAbstract readReview
In one paragraph

Review in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Review
  8. Article
  9. High Spatiotemporal Resolution Radial Encoding Single-Vessel fMRI.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  10. Specific and Nonuniform Brain States during Cold Perception in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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  18. Active neural coordination of motor behaviors with internal states.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Patricia Pais-RoldánMedical Imaging Physics, Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich 52425, Germany.
Celine MateoDepartment of Physics, University of California San Diego, La Jolla, CA 92093, USA.
Wen-Ju PanWallace H. Coulter Department of Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, GA 30322, USA.
Ben AclandDepartment of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, USA.
David KleinfeldDepartment of Physics, University of California San Diego, La Jolla, CA 92093, USA; Section of Neurobiology, University of California, La Jolla, San Diego, CA 92093, USA.
Lawrence H SnyderDepartment of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Xin YuAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Shella KeilholzWallace H. Coulter Department of Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, GA 30322, USA. Electronic address: shella.keilholz@bme.gatech.edu.
University of California, San Diego · USWashington University in St. Louis · USForschungszentrum Jülich · DEGeorgia Institute of Technology · USHarvard University · USThe Wallace H. Coulter Department of Biomedical Engineering · US

Funding

Project 4U19NS123717 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LINNINGER, ANDREAS A · 2021 to 2025
$13.4M
VISUAL-MOTOR TRANSFORMATIONS IN PARIETAL CORTEXR01EY012135 · NEI · WASHINGTON UNIVERSITY · PI SNYDER, LAWRENCE H · 2000 to 2023
$8.4M
Resilient versus fragile aspects of blood flow in the mammalian brainR35NS097265 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2017 to 2024
$6.8M
Resting state connectivity: Biophysical basis for and improved fMRI measurementsR01MH111438 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID, ROSEN, BRUCE R · 2016 to 2020
$5.2M
Contribution of Ultra Low Frequency LFPs to Functional MRIR01NS078095 · NINDS · EMORY UNIVERSITY · PI KEILHOLZ, SHELLA D · 2012 to 2022
$3.4M
Investigating the Thalamic Regulation of Neuro-Glio-Vascular Restoration Underlying Acute Coma Recovery with Multi-Modal fMRI in a Brainstem Coma Rodent ModelR01NS122904 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI YU, XIN · 2021 to 2025
$3.2M
Impact of locus coeruleus-derived tau pathology in a rodent model of early Alzheimer's diseaseR01AG062581 · NIA · EMORY UNIVERSITY · PI KEILHOLZ, SHELLA D, WEINSHENKER, DAVID · 2020 to 2024
$2.3M
Simultaneous functional MRI and Micro-Magnetic Nervous System StimulationR01NS120594 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AY, ILKNUR, BONMASSAR, GIORGIO · 2021 to 2021
$2.2M
Develop a multi-modal cross-scale fMRI platform with laminar-specific cellular recordings through multi-channel tapered photonic crystal fiber arrayRF1NS113278 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI YU, XIN · 2019 to 2019
$2.0M
Spatiotemporal signatures of neural activity and neurophysiology in the BOLD signalR01MH111416 · NIMH · EMORY UNIVERSITY · PI KEILHOLZ, SHELLA D · 2016 to 2020
$1.9M
Crossing space and time: uncovering the nonlinear dynamics of multimodal and multiscale brain activityR01EB029857 · NIBIB · EMORY UNIVERSITY · PI KEILHOLZ, SHELLA D, STANLEY, GARRETT B. · 2020 to 2021
$1.3M
Understanding overlap in resting state fMRI networks at the single cell level: a cross-species approachR34NS118618 · NINDS · WASHINGTON UNIVERSITY · PI BIJSTERBOSCH, JANINE DIANE, SNYDER, LAWRENCE H · 2020 to 2020
$709k
NEI NIH HHS R01 EY012135NIA NIH HHS R01 AG062581NIBIB NIH HHS R01 EB029857NIMH NIH HHS R01 MH111416NIMH NIH HHS R01 MH111438NIMH NIH HHS S10 MH124733NINDS NIH HHS R01 NS078095NINDS NIH HHS R01 NS120594NINDS NIH HHS R01 NS122904NINDS NIH HHS R34 NS118618NINDS NIH HHS R35 NS097265NINDS NIH HHS RF1 NS113278NINDS NIH HHS U19 NS123717
6 · The paper itself

Abstract

Functional connectivity, which reflects the spatial and temporal organization of intrinsic activity throughout the brain, is one of the most studied measures in human neuroimaging research. The noninvasive acquisition of resting state functional magnetic resonance imaging (rs-fMRI) allows the characterization of features designated as functional networks, functional connectivity gradients, and time-varying activity patterns that provide insight into the intrinsic functional organization of the brain and potential alterations related to brain dysfunction. Functional connectivity, hence, captures dimensions of the brain's activity that have enormous potential for both clinical and preclinical research. However, the mechanisms underlying functional connectivity have yet to be fully characterized, hindering interpretation of rs-fMRI studies. As in other branches of neuroscience, the identification of the neurophysiological processes that contribute to functional connectivity largely depends on research conducted on laboratory animals, which provide a platform where specific, multi-dimensional investigations that involve invasive measurements can be carried out. These highly controlled experiments facilitate the interpretation of the temporal correlations observed across the brain. Indeed, information obtained from animal experimentation to date is the basis for our current understanding of the underlying basis for functional brain connectivity. This review presents a compendium of some of the most critical advances in the field based on the efforts made by the animal neuroimaging community.

Indexed as

Magnetic Resonance ImagingModels, AnimalNeuroimagingAnimalsConnectomeRest

Identifiers

PMID34644593
PMCPMC9031339
OpenAlexW3205229638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.