Evidence map›Paper›PMID 34644575›Full record

ArticleCell reports2021

Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice.

Emily A L Wozniak, Zhao Chen, Sharan Paul, Praseuth Yang, Karla P Figueroa, Jill Friedrich, Tyler Tschumperlin, Michael Berken, Melissa Ingram, Christine Henzler and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Emily A L WozniakInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Zhao ChenInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Sharan PaulDepartment of Neurology, University of Utah, Salt Lake City, UT 84112, USA.
Praseuth YangInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Karla P FigueroaDepartment of Neurology, University of Utah, Salt Lake City, UT 84112, USA.
Jill FriedrichInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Tyler TschumperlinInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Michael BerkenInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Melissa IngramInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Christine HenzlerRISS Bioinformatics, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Stefan M PulstDepartment of Neurology, University of Utah, Salt Lake City, UT 84112, USA; Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: stefan.pulst@hsc.utah.edu.
Harry T OrrInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: orrxx002@umn.edu.
University of Minnesota · USUniversity of Utah · US

Funding

Cell Signaling and NeurodegenerationR01NS045667 · NINDS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ORR, HARRY T. · 2003 to 2021
$8.8M
Spinocerebellar Ataxia Type 2 Gene and Gene ProductR37NS033123 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M. · 2014 to 2020
$3.6M
Antisense Oligonucleotides for treating Spinocerebellar Ataxia Type 2U01NS103883 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M., SCOLES, DANIEL R · 2018 to 2020
$1.9M
NINDS NIH HHS R01 NS045667NINDS NIH HHS R37 NS033123NINDS NIH HHS U01 NS103883
6 · The paper itself

Abstract

Spinocerebellar ataxias (SCAs) are a group of genetic diseases characterized by progressive ataxia and neurodegeneration, often in cerebellar Purkinje neurons. A SCA1 mouse model, Pcp2-ATXN1[30Q]D776, has severe ataxia in absence of progressive Purkinje neuron degeneration and death. Previous RNA-seq analyses identify cerebellar upregulation of the peptide hormone cholecystokinin (Cck) in Pcp2-ATXN1[30Q]D776 mice. Importantly, absence of Cck1 receptor (Cck1R) in Pcp2-ATXN1[30Q]D776 mice confers a progressive disease with Purkinje neuron death. Administration of a Cck1R agonist, A71623, to Pcp2-ATXN1[30Q]D776;Cck

Indexed as

AnimalsAtaxin-1AtrophyBehavior, AnimalCalbindinsChemokines, CCCholecystokininDisease Models, AnimalFemaleGenetic Predisposition to DiseaseGuanine Nucleotide Exchange FactorsMaleMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, KnockoutA 71623Ataxin-1Atxn1 protein, mouseCalbindinsCcl28 protein, mouseChemokines, CCCholecystokininGuanine Nucleotide Exchange FactorsMechanistic Target of Rapamycin Complex 1NeuropeptidesPcp2 protein, mouseTetragastrincholecystokininmTORC1 signalingneuroprotectionPurkinje cellsspinocerebellar ataxia

Identifiers

PMID34644575
PMCPMC8916043
OpenAlexW3207056215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.